Browsing by Author "Gobalakrishnapillai, V"
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An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs
Voak, AA; Gobalakrishnapillai, V; Seifert, K; Balczo, E; Hu, L; Hall, BS; WILKINSON, SR (2013-08-14)Nitroaromatic prodrugs are used to treat a range of microbial infections with selectivity achieved by specific activation reactions. For trypanosomatid parasites this is mediated by type I nitroreductases (NTRs). Here, we ... -
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs
Hu, LQ; Wu, XH; Han, JY; Chen, L; Vass, SO; Browne, P; Hall, BS; Bot, C; Gobalakrishnapillai, V; Searle, PF (2011-07-01)