Browsing by Author "Fuchsberger, C"
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Associations of autozygosity with a broad range of human phenotypes
Clark, DW; Okada, Y; Moore, KHS; Mason, D; Pirastu, N; Gandin, I; Mattsson, H; Barnes, CLK; Lin, K; Zhao, JH (2019-10-31) -
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Sotoodehnia, N; Isaacs, A; de Bakker, PIW; Dorr, M; Newton-Cheh, C; Nolte, IM; van der Harst, P; Muller, M; Eijgelsheim, M; Alonso, A (2010-12) -
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young, WJ; Lahrouchi, N; Isaacs, A; Duong, TV; Foco, L; Ahmed, F; Brody, JA; Salman, R; Noordam, R; Benjamins, J-W (2022) -
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
Young, WJ; Haessler, J; Benjamins, J-W; Repetto, L; Yao, J; Isaacs, A; Harper, AR; Ramirez, J; Garnier, S; van Duijvenboden, S (2023-03-14)The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry ... -
The genetic architecture of type 2 diabetes
Fuchsberger, C; Flannick, J; Teslovich, TM; Mahajan, A; Agarwala, V; Gaulton, KJ; Ma, C; Fontanillas, P; Moutsianas, L; McCarthy, DJ (2016-08-04) -
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Arking, DE; Pulit, SL; Crotti, L; Van der Harst, P; Munroe, PB; Koopmann, TT; Sotoodehnia, N; Rossin, EJ; Morley, M; Wang, X (2014-08) -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, C; Teumer, A; Gorski, M; Chu, AY; Li, M; Mijatovic, V; Garnaas, M; Tin, A; Sorice, R; Li, Y (2016-01) -
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton, KJ; Ferreira, T; Lee, Y; Raimondo, A; Maegi, R; Reschen, ME; Mahajan, A; Locke, A; Rayner, NW; Robertson, N (2015-12) -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, S; Graham, SE; Wang, Y; Surakka, I; Ramdas, S; Zhu, X; Clarke, SL; Bhatti, KF; Vedantam, S; Winkler, TW (2022) -
KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.
Teumer, A; Trenkwalder, T; Kessler, T; Jamshidi, Y; van den Berg, ME; Kaess, B; Nelson, CP; Bastiaenen, R; De Bortoli, M; Rossini, A (2019-12-05)BACKGROUNDThe presence of an early repolarization pattern (ERP) on the surface ECG is associated with risk of ventricular fibrillation and sudden cardiac death. Family studies have shown that ERP is a highly heritable ... -
Mapping the human genetic architecture of COVID-19
Niemi, MEK; Karjalainen, J; Daly, M; Ganna, A; Mehtonen, J; Cordioli, M; Kaunisto, M; Pigazzini, S; Donner, K; Kivinen, K (2021) -
The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
Voight, BF; Kang, HM; Ding, J; Palmer, CD; Sidore, C; Chines, PS; Burtt, NP; Fuchsberger, C; Li, Y; Erdmann, J (2012-08) -
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ntalla, I; Weng, L-C; Cartwright, JH; Hall, AW; Sveinbjornsson, G; Tucker, NR; Choi, SH; Chaffin, MD; Roselli, C; Barnes, MR (2020-05-21) -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, S; Judd, J; Graham, SE; Kanoni, S; Wang, Y; Surakka, I; Wenz, B; Clarke, SL; Chesi, A; Wells, A (2022) -
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
Sterenborg, RBTM; Steinbrenner, I; Li, Y; Bujnis, MN; Naito, T; Marouli, E; Galesloot, TE; Babajide, O; Andreasen, L; Astrup, A (Nature Research, 2024-01-30)To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including ... -
The power of genetic diversity in genome-wide association studies of lipids
Graham, SE; Clarke, SL; Wu, K-HH; Kanoni, S; Zajac, GJM; Ramdas, S; Surakka, I; Ntalla, I; Vedantam, S; Winkler, TW (2021) -
The power of genetic diversity in genome-wide association studies of lipids (vol 600, pg 675, 2021)
Graham, SE; Clarke, SL; Wu, K-HH; Kanoni, S; Zajac, GJM; Ramdas, S; Surakka, I; Ntalla, I; Vedantam, S; Winkler, TW (2023) -
A saturated map of common genetic variants associated with human height
Yengo, L; Vedantam, S; Marouli, E; Sidorenko, J; Bartell, E; Sakaue, S; Graff, M; Eliasen, AU; Jiang, Y; Raghavan, S (2022) -
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
Li, M; Li, Y; Weeks, O; Mijatovic, V; Teumer, A; Huffman, JE; Tromp, G; Fuchsberger, C; Gorski, M; Lyytikäinen, L-P (2017-03)Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations ... -
The trans-ancestral genomic architecture of glycemic traits.
Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M (2021-05-31)Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide ...