Browsing by Author "Freund, SMV"
Now showing items 1-3 of 3
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CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.
Ochi, T; Quarantotti, V; Lin, H; Jullien, J; Rosa E Silva, I; Boselli, F; Barnabas, DD; Johnson, CM; McLaughlin, SH; Freund, SMV (2020-06-02)Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated ... -
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Liu, Y; Gupta, GD; Barnabas, DD; Agircan, FG; Mehmood, S; Wu, D; Coyaud, E; Johnson, CM; McLaughlin, SH; Andreeva, A (2018-04-30)Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is ... -
Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
Joseph, N; Al-Jassar, C; Johnson, CM; Andreeva, A; Barnabas, DD; Freund, SMV; Gergely, F; van Breugel, M (2018-05-29)Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality ...