Browsing by Author "Cutillas, PR"
Now showing items 21-37 of 37
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Integrin alpha V beta 6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas, JR; Moore, KM; Sproat, C; Mo, S; Wolanska, KI; Maldonado, H; Haider, S; Newman, D; Thomas, GJ; Zech, T (2019-08) -
Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data
Terfve, CDA; Wilkes, EH; Casado, P; Cutillas, PR; Saez-Rodriguez, J (2015-09) -
NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia
Afzal, TA; Luong, LA; Chen, D; Zhang, C; Yang, F; Chen, Q; An, W; Wilkes, E; Yashiro, K; Cutillas, PR (2016-12) -
Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition
Dermit, M; Casado, P; Rajeeve, V; Wilkes, EH; Foxler, DE; Campbell, H; Critchlow, S; Sharp, TV; Gribben, JG; Unwin, R (2017-05-11) -
Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
Arnandis, T; Monteiro, P; Adams, SD; Bridgeman, VL; Rajeeve, V; Gadaleta, E; Marzec, J; Chelala, C; Malanchi, I; Cutillas, PR (2018-11-19) -
Perineural invasion in pancreatic cancer: proteomic analysis and in vitro modelling.
Alrawashdeh, W; Jones, R; Dumartin, L; Radon, TP; Cutillas, PR; Feakins, RM; Dmitrovic, B; Demir, IE; Ceyhan, GO; Crnogorac-Jurcevic, T (FEBS Press and John Wiley & Sons Ltd., 2019-01-28)Perineural invasion (PNI) is a common and characteristic feature of pancreatic ductal adenocarcinoma (PDAC) that is associated with poor prognosis, tumor recurrence, and generation of pain. However, the molecular alterations ... -
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
Fearon, AE; Carter, EP; Clayton, NS; Wilkes, EH; Baker, A-M; Kapitonova, E; Bakhouche, BA; Tanner, Y; Wang, J; Gadaleta, E (Elsevier/Science Direct, 2018-02-27)Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ... -
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors
Casado, P; Alcolea, MP; Iorio, F; Rodriguez-Prados, J-C; Vanhaesebroeck, B; Saez-Rodriguez, J; Joel, S; Cutillas, PR (2013) -
Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells
Casado, P; Wilkes, EH; Miraki-Moud, F; Hadi, MM; Rio-Machin, A; Rajeeve, V; Pike, R; Iqbal, S; Marfa, S; Lea, N (2018-08) -
Proteomic Characterization of Acute Myeloid Leukemia for Precision Medicine
Casado, P; Cutillas, PR (2023) -
Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring
Hijazi, M; Smith, R; Rajeeve, V; Bessant, C; Cutillas, PR (Nature Publishing, 2020-01-20)Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments. We report a chemical phosphoproteomics ... -
Role of phosphoproteomics in the development of personalized cancer therapies
Cutillas, PR (2015-04) -
A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases
Montfort, A; Pearce, O; Maniati, E; Vincent, BG; Bixby, L; Bohm, S; Dowe, T; Wilkes, EH; Chakravarty, P; Thompson, R (2017-01-01) -
Systematic identification of biochemical networks in cancer cells by functional pathway inference analysis
Badshah, II; Cutillas, PR (2023) -
Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
Davidson, K; Grevitt, P; Contreras-Gerenas, MF; Bridge, KS; Hermida, M; Shah, KM; Mardakheh, FK; Stubbs, M; Burke, R; Casado, P (2021) -
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment
Pedicona, F; Casado, P; Hijazi, M; Gribben, JG; Rouault-Pierre, K; Cutillas, PR (2022) -
TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer
Lecker, LSM; Berlato, C; Maniati, E; Delaine-Smith, R; Pearce, OMT; Heath, O; Nichols, SJ; Trevisan, C; Novak, M; McDermott, J (2021)