Browsing Centre for Cell Biology and Cutaneous Research by Author "Maffucci, T"
Now showing items 1-15 of 15
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Class II phosphoinositide 3-kinase C2 beta regulates a novel signaling pathway involved in breast cancer progression
Chikh, A; Ferro, R; Abbott, JJ; Pineiro, R; Buus, R; Iezzi, M; Ricci, F; Bergamaschi, D; Ostano, P; Chiorino, G (2016-04-05) -
Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth.
Cisse, O; Quraishi, M; Gulluni, F; Guffanti, F; Mavrommati, I; Suthanthirakumaran, M; Oh, LCR; Schlatter, JN; Sarvananthan, A; Broggini, M (BMC (part of Springer Nature), 2019-11-21)BACKGROUND: Alteration of signalling pathways regulating cell cycle progression is a common feature of cancer cells. Several drugs targeting distinct phases of the cell cycle have been developed but the inability of many ... -
GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
Ferro, R; Adamska, A; Lattanzio, R; Mavrommati, I; Edling, CE; Arifin, SA; Fyffe, CA; Sala, G; Sacchetto, L; Chiorino, G (2018-12-06) -
Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors.
Mannella, V; Boehm, K; Celik, S; Ali, T; Mirza, AN; El Hasnaouy, M; Kaffa, A; Lyu, Y; Kafaei Golahmadi, D; Leigh, IM (MDPI, 2021-03-30)Cutaneous squamous cell carcinomas (cSCCs) account for about 20% of keratinocyte carcinomas, the most common cancer in the UK. Therapeutic options for cSCC patients who develop metastasis are limited and a better understanding ... -
Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy
Emmanouilidi, A; Casari, I; Akkaya, BG; Maffucci, T; Furic, L; Guffanti, F; Broggini, M; Chen, X; Maxuitenko, YY; Keeton, AB (2020-08) -
Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling
Maffucci, T; Falasca, M (2020-10) -
A novel regulatory mechanism links PLC gamma 1 to PDK1 ( vol 125, pg 3153, 2012)
Raimondi, C; Chikh, A; Wheeler, AP; Maffucci, T; Falasca, M (2017-03-01) -
Novel roles for class II Phosphoinositide 3-Kinase C2 beta in signalling pathways involved in prostate cancer cell invasion
Mavrommati, I; Cisse, O; Falasca, M; Maffucci, T (2016-03-17) -
Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119
Arifin, SA; Paternoster, S; Carlessi, R; Casari, I; Ekberg, JH; Maffucci, T; Newsholme, P; Rosenkilde, MM; Falasca, M (2018-09) -
Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas
Janus, JM; O'Shaughnessy, RFL; Harwood, CA; Maffucci, T (2017-07) -
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer
Emmanouilidi, A; Fyffe, CA; Ferro, R; Edling, CE; Capone, E; Sestito, S; Rapposelli, S; Lattanzio, R; Iacobelli, S; Sala, G (2019-05-14) -
Signalling Properties of Inositol Polyphosphates
Maffucci, T; Falasca, M (MDPI, 2020-11-12)Several studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led to the accumulation of new information regarding their cellular roles as well as new ... -
A Small Molecule Inhibitor of PDK1/PLC gamma 1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
Raimondi, C; Calleja, V; Ferro, R; Fantin, A; Riley, AM; Potter, BVL; Brennan, CH; Maffucci, T; Larijani, B; Falasca, M (2016-05-20) -
Targeting p63 Upregulation Abrogates Resistance to MAPK Inhibitors in Melanoma
Patel, A; Garcia, LF; Mannella, V; Gammon, L; Borg, T-M; Maffucci, T; Scatolini, M; Chiorino, G; Vergani, E; Rodolfo, M (2020-06-15) -
Targeting selective phosphoinositide-3-kinase isoforms as a novel strategy in cutaneous squamous cell carcinoma
Mannella, V; Bergamaschi, D; Harwood, C; Maffucci, T (2019)