Browsing Centre for Tumour Biology by Title
Now showing items 275-294 of 372
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Quantification of subclonal selection in cancer from bulk sequencing data
(2016-12-22)Recent studies have identified prevalent subclonal architectures within many cancer types. However, the temporal evolutionary dynamics that produce these subclonal architectures remain unknown. Here we measure evolutionary ... -
Rac1 Deletion Causes Thymic Atrophy
(2011-04-29) -
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
(2021-08)Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at ... -
Recurrent indigestion in a young adult.
(2010-12-01)Bochdalek hernias (BHs) arise due to congenital diaphragmatic defect and can result in gross displacement of abdominal tissues into the thorax. Although they are uncommon in occurrence, they usually present as serious ... -
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.
(2014-02)Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. PKCι is a human oncogene but whether this is related to its role ... -
Repeated negative biopsies in isolated high-grade cystic duct dysplasia with progression to adenocarcinoma.
(2014-09)Cystic and bile duct dysplasia is a rare histological finding, especially when found in the absence of an underlying malignancy. We report a patient who presented with jaundice and weight loss. Clinical and cytological ... -
Resolving genetic heterogeneity in cancer
(2019-07)