Browsing Centre for Tumour Biology by Title
Now showing items 107-126 of 372
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A faecal microbiota signature with high specificity for pancreatic cancer.
(2022-07)BACKGROUND: Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. OBJECTIVE: To explore the faecal and salivary microbiota as potential diagnostic biomarkers. ... -
Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma.
(2014)Hepatocellular cancer (HCC) is currently the third leading cause of cancer death worldwide. The prognosis of patients diagnosed with late-stage disease is dismal due to high resistance to conventional systemic therapies. ... -
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
(Macmillan Publishers, 2012-06)Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the cell cycle, apoptosis and response to oxidative stress. FOXOs have ... -
Functional versus non-functional intratumor heterogeneity in cancer.
(2016-07)Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary ... -
Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.
(2017-12)BACKGROUND & AIMS: The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors such as gastrinomas, characterized by ...