Browsing Centre for Tumour Biology by Title
Now showing items 295-314 of 372
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A role for the cancer-associated miR-106b similar to 25 cluster in neuronal stem cells
(Impact Journals, 2011-04)In the last decade, micro-RNAs (miRNAs) have emerged as major regulators of cell fate. They are involved in fine-tuning gene expression in normal developing tissues and are often aberrantly expressed in different disease ... -
The role of single-cell sequencing in studying tumour evolution.
(2021-05-26)Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell ... -
SNPnexus COVID: Facilitating the Analysis of COVID-19 Host Genetics
(Fortune Journals, 2021) -
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
(2019)Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth ...