dc.contributor.author | Farmer, AD | en_US |
dc.contributor.author | Wegeberg, A-ML | en_US |
dc.contributor.author | Brock, B | en_US |
dc.contributor.author | Hobson, AR | en_US |
dc.contributor.author | Mohammed, SD | en_US |
dc.contributor.author | Scott, SM | en_US |
dc.contributor.author | Bruckner-Holt, CE | en_US |
dc.contributor.author | Semler, JR | en_US |
dc.contributor.author | Hasler, WL | en_US |
dc.contributor.author | Hellström, PM | en_US |
dc.contributor.author | Drewes, AM | en_US |
dc.contributor.author | Brock, C | en_US |
dc.date.accessioned | 2018-01-12T10:53:22Z | |
dc.date.available | 2017-11-06 | en_US |
dc.date.issued | 2018-02 | en_US |
dc.date.submitted | 2017-12-21T11:03:14.496Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/31274 | |
dc.description.abstract | BACKGROUND: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. AIMS: To describe normative values for motility/contractility parameters across age, gender and testing centres. METHODS: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. RESULTS: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic loge motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times. CONCLUSIONS: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders. | en_US |
dc.description.sponsorship | Aalborg University, Novo Nordisk Foundation and the Research and Development Department, Uppsala University | en_US |
dc.format.extent | 391 - 400 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Aliment Pharmacol Ther | en_US |
dc.rights | "This is the peer reviewed version of the following article: Farmer AD, Wegeberg A-ML, Brock B, et al. Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country. Aliment Pharmacol Ther. 2018;47:391–400. https://doi.org/10.1111/apt.14438 which has been published in final form at https://doi.org/10.1111/apt.14438 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." | |
dc.title | Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country. | en_US |
dc.type | Article | |
dc.rights.holder | © 2017 John Wiley & Sons Ltd | |
dc.identifier.doi | 10.1111/apt.14438 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29210098 | en_US |
pubs.issue | 3 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 47 | en_US |
dcterms.dateAccepted | 2017-11-06 | en_US |