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dc.contributor.authorBouvette-Turcot, AA
dc.contributor.authorPluess, M
dc.contributor.authorBernier, A
dc.contributor.authorPennestri, MH
dc.contributor.authorLevitan, R
dc.contributor.authorSokolowski, MB
dc.contributor.authorKennedy, JL
dc.contributor.authorMinde, K
dc.contributor.authorSteiner, M
dc.contributor.authorPokhvisneva, I
dc.contributor.authorMeaney, MJ
dc.contributor.authorGaudreau, H
dc.contributor.authorMAVAN research team,
dc.date.accessioned2015-12-09T11:46:53Z
dc.date.issued2015-07-16
dc.date.issued2015-10
dc.date.issued2015-10
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/9688
dc.description.abstractBACKGROUND AND OBJECTIVES: Sleep problems are frequent in young children; however, children vary in the degree to which they are affected by poor sleep quality. We investigated whether a polymorphism in the serotonin transporter gene, which is linked to emotional function, is a potential moderator of the influences of sleep duration on infant temperament using longitudinal data. METHODS: We examined the interactive effects of average sleep duration between 6 and 36 months of age and the 5-HTTLPR genotype on negative emotionality/behavioral dysregulation at 36 months in 209 children recruited into a longitudinal birth cohort study. Triallelic genotyping of 5-HTTLPR was performed by looking at SLC6A4 genotype, focusing on the serotonin transporter-linked polymorphic region (5-HTTLPR) including the SNP polymorphism (rs23351). Child sleep habits were assessed with a maternal self-report questionnaire. RESULTS: After controlling for demographics and both previous and concurrent maternal depression, multiple linear regression analyses revealed a significant interaction effect of average sleep duration for the first 3 years of life and 5-HTTLPR genotype on child negative emotionality/behavioral dysregulation such that the effects were exclusive to those with low-expressing 5-HTTLPR genotypes. CONCLUSIONS: The results suggest differential susceptibility to the effect of sleep duration early in life, which reiterates that the short allele of the 5-HTTLPR represents a marker of increased environmental sensitivity regarding emotional development. Differential susceptibility theory posits that certain factors may increase an individual's susceptibility to the environment, in either a positive or negative fashion.
dc.description.sponsorshipSupported by the Canadian Institutes of Health Research.en_US
dc.format.extente914 - e921
dc.languageENG
dc.language.isoenen_US
dc.subjectCanada
dc.subjectChild, Preschool
dc.subjectCohort Studies
dc.subjectFemale
dc.subjectGenotype
dc.subjectHumans
dc.subjectInfant
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectPolymorphism, Genetic
dc.subjectRegression Analysis
dc.subjectSerotonin Plasma Membrane Transport Proteins
dc.subjectSleep
dc.subjectTemperament
dc.titleEffects of Genotype and Sleep on Temperament.
dc.typeJournal Article
dc.rights.holderCopyright © 2015 by the American Academy of Pediatrics
dc.identifier.doi10.1542/peds.2015-0080
dc.relation.isPartOfPediatrics
dc.relation.isPartOfPediatrics
dc.relation.isPartOfPediatrics
pubs.author-urlhttp://www.ncbi.nlm.nih.gov/pubmed/26371199
pubs.issue4
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering
pubs.organisational-group/Queen Mary University of London/Faculty of Science & Engineering/Biological and Chemical Sciences - Staff
pubs.publication-statusPublished
pubs.volume136


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