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dc.contributor.authorJacobs, BMen_US
dc.contributor.authorSchalk, Len_US
dc.contributor.authorDunne, Aen_US
dc.contributor.authorScalfari, Aen_US
dc.contributor.authorNandoskar, Aen_US
dc.contributor.authorGran, Ben_US
dc.contributor.authorMein, CAen_US
dc.contributor.authorSellers, Cen_US
dc.contributor.authorSpilker, Cen_US
dc.contributor.authorRog, Den_US
dc.contributor.authorVisentin, Een_US
dc.contributor.authorBezzina, ELen_US
dc.contributor.authorUzochukwu, Een_US
dc.contributor.authorTallantyre, Een_US
dc.contributor.authorWozniak, Een_US
dc.contributor.authorSacre, Een_US
dc.contributor.authorHassan-Smith, Gen_US
dc.contributor.authorFord, HLen_US
dc.contributor.authorHarris, Jen_US
dc.contributor.authorBradley, Jen_US
dc.contributor.authorBreedon, Jen_US
dc.contributor.authorBrooke, Jen_US
dc.contributor.authorKreft, KLen_US
dc.contributor.authorTuite Dalton, Ken_US
dc.contributor.authorGeorge, Ken_US
dc.contributor.authorPapachatzaki, Men_US
dc.contributor.authorO'Malley, Men_US
dc.contributor.authorPeter, Men_US
dc.contributor.authorMattoscio, Men_US
dc.contributor.authorRhule, Nen_US
dc.contributor.authorEvangelou, Nen_US
dc.contributor.authorVinod, Nen_US
dc.contributor.authorQuinn, Oen_US
dc.contributor.authorShamji, Ren_US
dc.contributor.authorKaimal, Ren_US
dc.contributor.authorBoulton, Ren_US
dc.contributor.authorTanveer, Ren_US
dc.contributor.authorMiddleton, Ren_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorBellfield, Ren_US
dc.contributor.authorHoque, Sen_US
dc.contributor.authorPatel, Sen_US
dc.contributor.authorRaj, Sen_US
dc.contributor.authorGumus, Sen_US
dc.contributor.authorMitchell, Sen_US
dc.contributor.authorSawcer, Sen_US
dc.contributor.authorArun, Ten_US
dc.contributor.authorPogreban, Ten_US
dc.contributor.authorBrown, T-Len_US
dc.contributor.authorBegum, Ten_US
dc.contributor.authorAntoine, Ven_US
dc.contributor.authorRashid, Wen_US
dc.contributor.authorNoyce, AJen_US
dc.contributor.authorSilber, Een_US
dc.contributor.authorMorris, Hen_US
dc.contributor.authorGiovannoni, Gen_US
dc.contributor.authorDobson, Ren_US
dc.date.accessioned2023-05-23T13:23:38Z
dc.date.issued2023-05-17en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/88025
dc.description.abstractPURPOSE: Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis (ADAMS) project aims to gather genetic and phenotypic data on a large cohort of ancestrally-diverse individuals with MS living in the UK. PARTICIPANTS: Adults with self-reported MS from diverse ancestral backgrounds. Recruitment is via clinical sites, online (https://app.mantal.co.uk/adams) or the UK MS Register. We are collecting demographic and phenotypic data using a baseline questionnaire and subsequent healthcare record linkage. We are collecting DNA from participants using saliva kits (Oragene-600) and genotyping using the Illumina Global Screening Array V.3. FINDINGS TO DATE: As of 3 January 2023, we have recruited 682 participants (n=446 online, n=55 via sites, n=181 via the UK MS Register). Of this initial cohort, 71.2% of participants are female, with a median age of 44.9 years at recruitment. Over 60% of the cohort are non-white British, with 23.5% identifying as Asian or Asian British, 16.2% as Black, African, Caribbean or Black British and 20.9% identifying as having mixed or other backgrounds. The median age at first symptom is 28 years, and median age at diagnosis is 32 years. 76.8% have relapsing-remitting MS, and 13.5% have secondary progressive MS. FUTURE PLANS: Recruitment will continue over the next 10 years. Genotyping and genetic data quality control are ongoing. Within the next 3 years, we aim to perform initial genetic analyses of susceptibility and severity with a view to replicating the findings from European-ancestry studies. In the long term, genetic data will be combined with other datasets to further cross-ancestry genetic discoveries.en_US
dc.format.extente071656 - ?en_US
dc.languageengen_US
dc.relation.ispartofBMJ Openen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectGENETICSen_US
dc.subjectMultiple sclerosisen_US
dc.subjectNeurologyen_US
dc.subjectAdulten_US
dc.subjectHumansen_US
dc.subjectFemaleen_US
dc.subjectMiddle Ageden_US
dc.subjectMaleen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectMultiple Sclerosis, Chronic Progressiveen_US
dc.subjectMultiple Sclerosis, Relapsing-Remittingen_US
dc.subjectGenetic Association Studiesen_US
dc.subjectUnited Kingdomen_US
dc.titleADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK.en_US
dc.typeArticle
dc.identifier.doi10.1136/bmjopen-2023-071656en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37197821en_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume13en_US
qmul.funderGenomic determinants of Multiple Sclerosis susceptibility in an ethnically diverse population::Medical Research Councilen_US


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States