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dc.contributor.authorChen, Sen_US
dc.contributor.authorGuan, Fen_US
dc.contributor.authorCandotti, Fen_US
dc.contributor.authorBenlagha, Ken_US
dc.contributor.authorCamara, NOSen_US
dc.contributor.authorHerrada, AAen_US
dc.contributor.authorJames, LKen_US
dc.contributor.authorLei, Jen_US
dc.contributor.authorMiller, Hen_US
dc.contributor.authorKubo, Men_US
dc.contributor.authorNing, Qen_US
dc.contributor.authorLiu, Cen_US
dc.date.accessioned2022-09-22T11:12:03Z
dc.date.available2022-07-26en_US
dc.date.issued2022en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/80667
dc.description.abstractB cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.en_US
dc.format.extent988536 - ?en_US
dc.languageengen_US
dc.relation.ispartofFront Immunolen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.subjectB cellsen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectantibodyen_US
dc.subjectmemory B cellsen_US
dc.subjectvaccinationen_US
dc.subjectCOVID-19en_US
dc.subjectHumansen_US
dc.subjectLymphocyte Counten_US
dc.subjectSARS-CoV-2en_US
dc.subjectVaccinationen_US
dc.subjectViral Vaccinesen_US
dc.titleThe role of B cells in COVID-19 infection and vaccination.en_US
dc.typeArticle
dc.rights.holder© 2022 Chen, Guan, Candotti, Benlagha, Camara, Herrada, James, Lei, Miller, Kubo, Ning and Liu.
dc.identifier.doi10.3389/fimmu.2022.988536en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36110861en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume13en_US
dcterms.dateAccepted2022-07-26en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.funder.project541084ed-28d5-44fd-a7a0-a48e11e248f9en_US


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