dc.contributor.author | Bestawros, M | en_US |
dc.contributor.author | Chidumayo, T | en_US |
dc.contributor.author | Blevins, M | en_US |
dc.contributor.author | Canipe, A | en_US |
dc.contributor.author | Bala, J | en_US |
dc.contributor.author | Kelly, P | en_US |
dc.contributor.author | Filteau, S | en_US |
dc.contributor.author | Shepherd, BE | en_US |
dc.contributor.author | Heimburger, DC | en_US |
dc.contributor.author | Koethe, JR | en_US |
dc.date.accessioned | 2015-06-15T16:37:36Z | |
dc.date.issued | 2015-03 | en_US |
dc.identifier.issn | 2155-6113 | en_US |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/7694 | |
dc.description | This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited. | en_US |
dc.description.abstract | INTRODUCTION: Persistent systemic inflammation is associated with mortality among undernourished, HIV-infected adults starting antiretroviral therapy (ART) in sub-Saharan Africa, but the etiology of these deaths is not well understood. We hypothesized that greater systemic inflammation is accompanied by cardiovascular dysfunction over the first 12 weeks of ART. METHODS: In a prospective cohort of 33 undernourished (body mass index <18.5 kg/m2) Zambian adults starting ART, we measured C-reactive protein (CRP), tumor necrosis factor-α receptor 1 (TNF-α R1), and soluble CD163 and CD14 at baseline and 12 weeks. An EndoPAT device measured the reactive hyperemia index (LnRHI; a measure of endothelial responsiveness), peripheral augmentation index (AI; a measure of arterial stiffness), and heart rate variability (HRV; a general marker of autonomic tone and cardiovascular health) at the same time points. We assessed paired changes in inflammation and cardiovascular parameters, and relationships independent of time point (adjusted for age, sex, and CD4+ T-cell count) using linear mixed models. RESULTS: Serum CRP decreased (median change -3.5 mg/l, p=0.02), as did TNF-α R1 (-0.31 ng/ml, p<0.01), over the first 12 weeks of ART. A reduction in TNF-α R1 over 12 weeks was associated with an increase in LnRHI (p=0.03), and a similar inverse relationship was observed for CRP and LnRHI (p=0.07). AI increased in the cohort as a whole over 12 weeks, and a reduction in sCD163 was associated with a rise in the AI score (p=0.04). In the pooled analysis of baseline and 12 week data, high CRP was associated with lower HRV parameters (RMSSD, p=0.01; triangular index, p<0.01), and higher TNF- α R1 accompanied lower HRV (RMSSD, p=0.07; triangular index, p=0.06). CONCLUSIONS: Persistent inflammation was associated with impaired cardiovascular health over the first 12 weeks of HIV treatment among undernourished adults in Africa, suggesting cardiac events may contribute to high mortality in this population. | en_US |
dc.description.sponsorship | This work was supported by the Vanderbilt
Meharry Center for AIDS Research (NIH grant number P30 AI54999); the NIH
Fogarty International Center, Office of the Director, National Institutes of Health,
National Heart, Blood, and Lung Institute, and National Institute of Mental Health,
through the Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows
(grant number R25 TW009337); the National Center for Advancing Translational
Sciences (CTSA award number UL1TR000445) and the European and Developing
Countries Clinical Trials Partnership (grant IP.2009.33011.004). | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | J AIDS Clin Res | en_US |
dc.subject | HIV | en_US |
dc.subject | antiretroviral therapy | en_US |
dc.subject | cardiovascular | en_US |
dc.subject | inflammation | en_US |
dc.subject | nutrition | en_US |
dc.subject | sub-Saharan Africa | en_US |
dc.title | Increased systemic inflammation is associated with cardiac and vascular dysfunction over the first 12 weeks of antiretroviral therapy among undernourished, HIV-infected adults in Southern Africa. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.4172/2155-6113.1000431 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26038711 | en_US |
pubs.issue | 3 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 6 | en_US |