Show simple item record

dc.contributor.authorRian, K
dc.contributor.authorEsteban-Medina, M
dc.contributor.authorHidalgo, MR
dc.contributor.authorÇubuk, C
dc.contributor.authorFalco, MM
dc.contributor.authorLoucera, C
dc.contributor.authorGunyel, D
dc.contributor.authorOstaszewski, M
dc.contributor.authorPeña-Chilet, M
dc.contributor.authorDopazo, J
dc.identifier.citationRian, K., Esteban-Medina, M., Hidalgo, M.R. et al. Mechanistic modeling of the SARS-CoV-2 disease map. BioData Mining 14, 5 (2021).
dc.description.abstractHere we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map. In this framework, the detailed activity of the human signaling circuits related to the viral infection, covering from the entry and replication mechanisms to the downstream consequences as inflammation and antigenic response, can be inferred from gene expression experiments. Moreover, the effect of potential interventions, such as knock-downs, or drug effects (currently the system models the effect of more than 8000 DrugBank drugs) can be studied. This freely available tool not only provides an unprecedentedly detailed view of the mechanisms of viral invasion and the consequences in the cell but has also the potential of becoming an invaluable asset in the search for efficient antiviral treatments.en_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofBioData Min
dc.rightsCreative Commons Attribution 4.0 International License
dc.subjectDrug discoveryen_US
dc.subjectMechanistic modelingen_US
dc.subjectSignaling pathwayen_US
dc.subjectSystems biologyen_US
dc.titleMechanistic modeling of the SARS-CoV-2 disease map.en_US
dc.rights.holder© The Author(s). 2021
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution 4.0 International License
Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International License