Novel ylidic phosphoryl compounds from halogenated furan-2,5-diones with trivalent phosphorus esters: Application of this approach to new trisphosphonates containing a geminal bisphosphonate unit
1013 - 1027
Phosphorus, Sulfur and Silicon and the Related Elements
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© 2014 Taylor & Francis Group, LLC. The reactions of trivalent phosphorus esters, including trialkyl phosphites, dialkyl phosphonites, and alkyl phosphinites, with 3-halo-and 3,4-dihalo-furan-2,5-diones has been shown to lead to the formation of novel phosphorus ylides possessing additional phosphoryl-containing groups. For the reaction of 3,4-dihalo-furan-2,5-diones with trialkyl phosphites, the products are trialkoxyphosphonium ylides containing an adjacent geminal bisphosphonate unit. These can be used to provide a convenient route to novel 2,3,3-tris(dialkoxyphosphoryl)-substituted propionate esters which can be hydrolyzed to give the corresponding novel trisphosphonic monocarboxylic acid.