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dc.contributor.authorMcDonald, Suzanna Leonie Rose
dc.date.accessioned2011-03-29T15:12:35Z
dc.date.available2011-03-29T15:12:35Z
dc.date.issued2010
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/667
dc.descriptionPhDen_US
dc.description.abstractThis thesis examines both humoral and cellular adaptive immune responses to varicella vaccination (up to 18 months post immunisation), in an ethnically diverse population of healthcare workers. Using two parameters of humoral immunity at six weeks post first vaccination; (avidity readings 60%, and a TRFIA reading 400mIU/mL) a cut-off of 130mIU/mL was defined for a more sensitive in house immuno assay (TRFIA), in this vaccinated adult population. Using these cut-offs, three patterns of antibody responses were identified; primary responders who seroconverted following vaccination, secondary responders who had pre-existing immunity and subjects who responded poorly to vaccination. Demographic and immunological characteristics of each subset were examined. An association between black ethnicity and lower antibody titre to vaccination in primary responders was identified, whilst Caucasians were more likely to have a history and pre-existing immunity, in keeping with the epidemiology of chickenpox in temperate climates. The follow-up study revealed that affinity maturation to VZV can take longer than 18 months in response to vaccination. At follow-up, 25% of subjects recruited at this time point were seronegative by TRFIA. Seroconversion after two doses of vaccine and a TRFIA titre of <500mIU/ml after two doses were significantly associated with waning antibody titre over time. Positive IFN- ELISPOT responses at 18 months did not necessarily correspond with TRFIA seropositive status. 3en_US
dc.language.isoenen_US
dc.subjectMedicineen_US
dc.titleCharacterisation of immune responses to varicella vaccination in relation to clinical outcomeen_US
dc.typeThesisen_US
dc.rights.holderThe copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author


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  • Theses [2793]
    Theses Awarded by Queen Mary University of London

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