• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    In the eye of the storm: T cell behavior in the inflammatory microenvironment. 
    •   QMRO Home
    • William Harvey Research Institute
    • Centre for Endocrinology
    • In the eye of the storm: T cell behavior in the inflammatory microenvironment.
    •   QMRO Home
    • William Harvey Research Institute
    • Centre for Endocrinology
    • In the eye of the storm: T cell behavior in the inflammatory microenvironment.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    In the eye of the storm: T cell behavior in the inflammatory microenvironment.

    View/Open
    Published version (460.0Kb)
    Volume
    2
    Pagination
    146 - 155
    Journal
    Am J Clin Exp Immunol
    Issue
    2
    ISSN
    2164-7712
    Metadata
    Show full item record
    Abstract
    Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently adaptive immune cells and the injured tissue itself. T lymphocytes are key players in the ensuing adaptive immunity and their proper function is instrumental to a successful outcome of immune protection. The site of inflammation is a "harsh" environment in which T cells are exposed to numerous factors that might influence their behavior. Low pH and oxygen concentration, high lactate and organic acid content as well as free fatty acids and reactive oxygen species are found in the inflammatory microenvironment. All these components affect T cells as well as other immune cells during the immune response and impact on the development of chronic inflammation. We here overview the effects of a number of factors present in the inflammatory microenvironment on T cell function and migration and discuss the potential relevance of these components as targets for therapeutic intervention in autoimmune and chronic inflammatory diseases.
    Authors
    Haas, R; Marelli-Berg, F; Mauro, C
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/6580
    Collections
    • Centre for Endocrinology [527]
    Language
    eng
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.