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dc.contributor.authorCheong, J L Y
dc.contributor.authorde Pablo-Fernandez, E
dc.contributor.authorFoltynie, T
dc.contributor.authorNoyce, A
dc.date.accessioned2020-06-08T16:00:58Z
dc.date.available2020-03-31
dc.date.available2020-06-08T16:00:58Z
dc.date.issued2020-04-24
dc.identifier.citationCheong, Julia L.Y. et al. ‘The Association Between Type 2 Diabetes Mellitus and Parkinson’s Disease’. 1 Jan. 2020 : 1 – 15.en_US
dc.identifier.issn1877-718X
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/64717
dc.description.abstractIn recent years, an emerging body of evidence has forged links between Parkinson’s disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with T2DM appear to be at increased risk of developing PD, as well as experiencing faster progression and a more severe phenotype of PD, with the effects being potentially mediated by several common cellular pathways. The insulin signalling pathway, for example, may be responsible for neurodegeneration via affecting insulin dysregulation, aggregation of amyloids, neuroinflammation, mitochondrial dysfunction and altered synaptic plasticity. In light of these potential shared disease mechanisms, clinical trials are now investigating the use of established diabetes drugs targeting insulin resistance in the management of PD. This review will discuss the epidemiological links between T2DM and PD, the potential shared cellular mechanisms, and assess the relevant treatment options for disease modification of PD.en_US
dc.publisherIOS Pressen_US
dc.relation.ispartofJournal of Parkinson's Disease
dc.rightsNon-commercial use only
dc.titleThe Association Between Type 2 Diabetes Mellitus and Parkinson’s Diseaseen_US
dc.typeArticleen_US
dc.identifier.doiDOI: 10.3233/JPD-191900
pubs.notesNot knownen_US
pubs.publication-statusAccepteden_US
dcterms.dateAccepted2020-03-31
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.funder.project483cf8e1-88a1-4b8b-aecb-8402672d45f8en_US


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