dc.contributor.author | Fitzpatrick, SF | |
dc.contributor.author | Lambden, S | |
dc.contributor.author | Macias, D | |
dc.contributor.author | Puthucheary, Z | |
dc.contributor.author | Pietsch, S | |
dc.contributor.author | Mendil, L | |
dc.contributor.author | McPhail, MJW | |
dc.contributor.author | Johnson, RS | |
dc.date.accessioned | 2020-06-02T09:34:42Z | |
dc.date.available | 2020-02-11 | |
dc.date.available | 2020-06-02T09:34:42Z | |
dc.date.issued | 2020-03-03 | |
dc.identifier.citation | Citation: Fitzpatrick SF, Lambden S, Macias D, Puthucheary Z, Pietsch S, Mendil L, McPhail MJW and Johnson RS (2020) 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. Front. Physiol. 11:147. doi: 10.3389/fphys.2020.00147 | en_US |
dc.identifier.issn | 1664-042X | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/64569 | |
dc.description.abstract | The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and in human septic patients. We further show that enhanced activation of the enzymes responsible for 2-HG degradation, D- and L-2-HGDH, underlie this effect. To determine the role of supplementation with 2HG, we carried out co-administration of LPS and 2HG. This co-administration in mice modulates a number of aspects of physiological responses to LPS, and in particular, protects against LPS-induced hypothermia. Our results identify a novel role for 2HG in endotoxemia pathophysiology, and suggest that this metabolite may be a critical diagnostic and therapeutic target for sepsis. | en_US |
dc.format.extent | 147 - ? | |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.relation.ispartof | Frontiers in Physiology | |
dc.rights | Creative Commons Attribution License (CC BY) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | 2-hydroxyglutarate | en_US |
dc.subject | 2-hydroxygluterate dehydrogenase | en_US |
dc.subject | endotoxemia | en_US |
dc.subject | hypothermia | en_US |
dc.subject | iNOS | en_US |
dc.subject | sepsis | en_US |
dc.title | 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2020 Fitzpatrick, Lambden, Macias, Puthucheary, Pietsch, Mendil, McPhail and Johnson | |
dc.identifier.doi | 10.3389/fphys.2020.00147 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32194434 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 11 | en_US |
dcterms.dateAccepted | 2020-02-11 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |