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dc.contributor.authorFitzpatrick, SF
dc.contributor.authorLambden, S
dc.contributor.authorMacias, D
dc.contributor.authorPuthucheary, Z
dc.contributor.authorPietsch, S
dc.contributor.authorMendil, L
dc.contributor.authorMcPhail, MJW
dc.contributor.authorJohnson, RS
dc.date.accessioned2020-06-02T09:34:42Z
dc.date.available2020-02-11
dc.date.available2020-06-02T09:34:42Z
dc.date.issued2020-03-03
dc.identifier.citationCitation: Fitzpatrick SF, Lambden S, Macias D, Puthucheary Z, Pietsch S, Mendil L, McPhail MJW and Johnson RS (2020) 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. Front. Physiol. 11:147. doi: 10.3389/fphys.2020.00147en_US
dc.identifier.issn1664-042X
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/64569
dc.description.abstractThe metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and in human septic patients. We further show that enhanced activation of the enzymes responsible for 2-HG degradation, D- and L-2-HGDH, underlie this effect. To determine the role of supplementation with 2HG, we carried out co-administration of LPS and 2HG. This co-administration in mice modulates a number of aspects of physiological responses to LPS, and in particular, protects against LPS-induced hypothermia. Our results identify a novel role for 2HG in endotoxemia pathophysiology, and suggest that this metabolite may be a critical diagnostic and therapeutic target for sepsis.en_US
dc.format.extent147 - ?
dc.languageeng
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofFrontiers in Physiology
dc.rightsCreative Commons Attribution License (CC BY)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject2-hydroxyglutarateen_US
dc.subject2-hydroxygluterate dehydrogenaseen_US
dc.subjectendotoxemiaen_US
dc.subjecthypothermiaen_US
dc.subjectiNOSen_US
dc.subjectsepsisen_US
dc.title2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia.en_US
dc.typeArticleen_US
dc.rights.holder© 2020 Fitzpatrick, Lambden, Macias, Puthucheary, Pietsch, Mendil, McPhail and Johnson
dc.identifier.doi10.3389/fphys.2020.00147
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32194434en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume11en_US
dcterms.dateAccepted2020-02-11
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
rioxxterms.funder.project483cf8e1-88a1-4b8b-aecb-8402672d45f8en_US


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Except where otherwise noted, this item's license is described as Creative Commons Attribution License (CC BY)