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dc.contributor.authorHurwitz, I
dc.contributor.authorFieck, A
dc.contributor.authorRead, A
dc.contributor.authorHillesland, H
dc.contributor.authorKlein, N
dc.contributor.authorKang, A
dc.contributor.authorDurvasula, R
dc.date.accessioned2020-04-29T11:13:13Z
dc.date.available2011-10-01
dc.date.available2020-04-29T11:13:13Z
dc.date.issued2011-11-01
dc.identifier.citationHurwitz I, Fieck A, Read A, Hillesland H, Klein N, Kang A, Durvasula R. Paratransgenic Control of Vector Borne Diseases. Int J Biol Sci 2011; 7(9):1334-1344. doi:10.7150/ijbs.7.1334. Available from http://www.ijbs.com/v07p1334.htmen_US
dc.identifier.issn1449-2288
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/63825
dc.description.abstractConventional methodologies to control vector borne diseases with chemical pesticides are often associated with environmental toxicity, adverse effects on human health and the emergence of insect resistance. In the paratransgenic strategy, symbiotic or commensal microbes of host insects are transformed to express gene products that interfere with pathogen transmission. These genetically altered microbes are re-introduced back to the insect where expression of the engineered molecules decreases the host's ability to transmit the pathogen. We have successfully utilized this strategy to reduce carriage rates of Trypanosoma cruzi, the causative agent of Chagas disease, in the triatomine bug, Rhodnius prolixus, and are currently developing this methodology to control the transmission of Leishmania donovani by the sand fly Phlebotomus argentipes. Several effector molecules, including antimicrobial peptides and highly specific single chain antibodies, are currently being explored for their anti-parasite activities in these two systems. In preparation for eventual field use, we are actively engaged in risk assessment studies addressing the issue of horizontal gene transfer from the modified bacteria to environmental microbes.en_US
dc.description.sponsorshipThis work is supported by NIH/NIAID RO1AI66045-4 (RD). Nuance multispectral images of sand flies were generated in the University of New Mexico & Cancer Center Fluorescence Microscopy Shared Resource, funded as detailed on: http://hsc.unm.edu/crtc/microscopy/Facility.html.en_US
dc.format.extent1334 - 1344
dc.language.isoenen_US
dc.publisherIvyspring International Publisher.en_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
dc.rightsCC-BY-NC*
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectParatransgenesisen_US
dc.subjectChagas diseaseen_US
dc.subjecttriatomine bugsen_US
dc.subjectvisceral leishmaniasisen_US
dc.subjectsand fliesen_US
dc.subjectmicrobiologyen_US
dc.subjectrisk assessmenten_US
dc.subjecthorizontal gene transferen_US
dc.titleParatransgenic Control of Vector Borne Diseasesen_US
dc.typeArticleen_US
dc.rights.holderIvyspring International Publisher.
dc.identifier.doi10.7150/ijbs.7.1334
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000298011000011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue9en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume7en_US
dcterms.dateAccepted2011-10-01
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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