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dc.contributor.authorWackers, Gen_US
dc.contributor.authorVandenryt, Ten_US
dc.contributor.authorCornelis, Pen_US
dc.contributor.authorKellens, Een_US
dc.contributor.authorThoelen, Ren_US
dc.contributor.authorDe Ceuninck, Wen_US
dc.contributor.authorLosada-Pérez, Pen_US
dc.contributor.authorvan Grinsven, Ben_US
dc.contributor.authorPeeters, Men_US
dc.contributor.authorWagner, Pen_US
dc.date.accessioned2015-01-20T15:44:00Z
dc.date.available2014-06-17en_US
dc.date.issued2014-06-20en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/6364
dc.description.abstractIn this work we present the first steps towards a molecularly imprinted polymer (MIP)-based biomimetic sensor array for the detection of small organic molecules via the heat-transfer method (HTM). HTM relies on the change in thermal resistance upon binding of the target molecule to the MIP-type receptor. A flow-through sensor cell was developed, which is segmented into four quadrants with a volume of 2.5 μL each, allowing four measurements to be done simultaneously on a single substrate. Verification measurements were conducted, in which all quadrants received a uniform treatment and all four channels exhibited a similar response. Subsequently, measurements were performed in quadrants, which were functionalized with different MIP particles. Each of these quadrants was exposed to the same buffer solution, spiked with different molecules, according to the MIP under analysis. With the flow cell design we could discriminate between similar small organic molecules and observed no significant cross-selectivity. Therefore, the MIP array sensor platform with HTM as a readout technique, has the potential to become a low-cost analysis tool for bioanalytical applications.en_US
dc.description.sponsorshipThis work is supported by the Life Science Initiative of the Province of Limburg, by the Special Research Funds of Hasselt University ,the Methusalem Nano Antwerp Hasselt, the European Funds for Regional Development MicroBioMed and the FWO projects G09971NN and G0B6213Nen_US
dc.format.extent11016 - 11030en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofSensors (Basel)en_US
dc.subjectBiomimeticsen_US
dc.subjectDimethylpolysiloxanesen_US
dc.subjectEnergy Transferen_US
dc.subjectEquipment Designen_US
dc.subjectEquipment Failure Analysisen_US
dc.subjectMicroarray Analysisen_US
dc.subjectMicrofluidic Analytical Techniquesen_US
dc.subjectMolecular Imprintingen_US
dc.subjectMolecular Weighten_US
dc.subjectOrganic Chemicalsen_US
dc.subjectThermal Conductivityen_US
dc.subjectThermographyen_US
dc.subjectTransducersen_US
dc.titleArray formatting of the heat-transfer method (HTM) for the detection of small organic molecules by molecularly imprinted polymers.en_US
dc.typeArticle
dc.identifier.doi10.3390/s140611016en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24955945en_US
pubs.issue6en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume14en_US
dcterms.dateAccepted2014-06-17en_US


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