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"This is the peer reviewed version of the following article: Donos, N., Calciolari, E., Brusselaers, N., Goldoni, M., Bostanci, N. and Belibasakis, G. (2020), The adjunctive use of host modulators in non‐surgical periodontal therapy. A systematic review of randomized, placebo‐controlled clinical studies. J Clin Periodontol. Accepted Author Manuscript. doi:10.1111/jcpe.13232 which has been published in final form at https://doi.org/10.1111/jcpe.13232. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."