dc.contributor.author | Kurochkin, MA | en_US |
dc.contributor.author | Sindeeva, OA | en_US |
dc.contributor.author | Brodovskaya, EP | en_US |
dc.contributor.author | Gai, M | en_US |
dc.contributor.author | Frueh, J | en_US |
dc.contributor.author | Su, L | en_US |
dc.contributor.author | Sapelkin, A | en_US |
dc.contributor.author | Tuchin, VV | en_US |
dc.contributor.author | Sukhorukov, GB | en_US |
dc.date.accessioned | 2020-02-19T11:45:38Z | |
dc.date.available | 2020-01-13 | en_US |
dc.date.issued | 2020-05 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/62822 | |
dc.description.abstract | Photosensitive polymeric three-dimensional microstructured film (PTMF) is a new type of patterned polymeric films functionalized with an array of sealed hollow 3D containers. The microstructured system with enclosed chemicals provides a tool for the even distribution of biologically active substances on a given surface that can be deposited on medical implants or used as a cells substrate. In this work, we proposed a way for photothermally activating and releasing encapsulated substances at picogram amounts from the PTMF surface in different environments using laser radiation delivered with a multimode optical fiber. The photosensitive PTMFs were prepared by the layer-by-layer (LbL) assembly from alternatively charged polyelectrolytes followed by covering with a layer of hydrophobic polylactic acid (PLA) and a layer of gold nanoparticles (AuNPs). Moreover, the typical photothermal cargo release amounts were determined on the surface of the PTMF for a range of laser powers delivered to films placed in the air, deionized (DI) water, and 1% agarose gel. The agarose gel was used as a soft tissue model for developing a technique for the laser activation of PTMFs deep in tissues using optical waveguides. The number of PTMF chambers activated by a near-infrared (NIR) laser beam was evaluated as the function of optical parameters. | en_US |
dc.format.extent | 110664 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Mater Sci Eng C Mater Biol Appl | en_US |
dc.rights | https://doi.org/10.1016/j.msec.2020.110664 | |
dc.subject | Chamber array | en_US |
dc.subject | Controlled drug delivery | en_US |
dc.subject | Infrared laser | en_US |
dc.subject | Microstructured film | en_US |
dc.subject | Optical fiber | en_US |
dc.subject | Polyelectrolyte multilayer | en_US |
dc.title | Laser-triggered drug release from polymeric 3-D micro-structured films via optical fibers. | en_US |
dc.type | Article | |
dc.rights.holder | © 2020 Elsevier | |
dc.identifier.doi | 10.1016/j.msec.2020.110664 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32204092 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 110 | en_US |
dcterms.dateAccepted | 2020-01-13 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |