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dc.contributor.authorKurochkin, MAen_US
dc.contributor.authorSindeeva, OAen_US
dc.contributor.authorBrodovskaya, EPen_US
dc.contributor.authorGai, Men_US
dc.contributor.authorFrueh, Jen_US
dc.contributor.authorSu, Len_US
dc.contributor.authorSapelkin, Aen_US
dc.contributor.authorTuchin, VVen_US
dc.contributor.authorSukhorukov, GBen_US
dc.date.accessioned2020-02-19T11:45:38Z
dc.date.available2020-01-13en_US
dc.date.issued2020-05en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/62822
dc.description.abstractPhotosensitive polymeric three-dimensional microstructured film (PTMF) is a new type of patterned polymeric films functionalized with an array of sealed hollow 3D containers. The microstructured system with enclosed chemicals provides a tool for the even distribution of biologically active substances on a given surface that can be deposited on medical implants or used as a cells substrate. In this work, we proposed a way for photothermally activating and releasing encapsulated substances at picogram amounts from the PTMF surface in different environments using laser radiation delivered with a multimode optical fiber. The photosensitive PTMFs were prepared by the layer-by-layer (LbL) assembly from alternatively charged polyelectrolytes followed by covering with a layer of hydrophobic polylactic acid (PLA) and a layer of gold nanoparticles (AuNPs). Moreover, the typical photothermal cargo release amounts were determined on the surface of the PTMF for a range of laser powers delivered to films placed in the air, deionized (DI) water, and 1% agarose gel. The agarose gel was used as a soft tissue model for developing a technique for the laser activation of PTMFs deep in tissues using optical waveguides. The number of PTMF chambers activated by a near-infrared (NIR) laser beam was evaluated as the function of optical parameters.en_US
dc.format.extent110664 - ?en_US
dc.languageengen_US
dc.relation.ispartofMater Sci Eng C Mater Biol Applen_US
dc.rightshttps://doi.org/10.1016/j.msec.2020.110664
dc.subjectChamber arrayen_US
dc.subjectControlled drug deliveryen_US
dc.subjectInfrared laseren_US
dc.subjectMicrostructured filmen_US
dc.subjectOptical fiberen_US
dc.subjectPolyelectrolyte multilayeren_US
dc.titleLaser-triggered drug release from polymeric 3-D micro-structured films via optical fibers.en_US
dc.typeArticle
dc.rights.holder© 2020 Elsevier
dc.identifier.doi10.1016/j.msec.2020.110664en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32204092en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume110en_US
dcterms.dateAccepted2020-01-13en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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