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dc.contributor.authorKraja, AT
dc.contributor.authorCook, JP
dc.contributor.authorWarren, HR
dc.contributor.authorSurendran, P
dc.contributor.authorLiu, C
dc.contributor.authorEvangelou, E
dc.contributor.authorManning, AK
dc.contributor.authorGrarup, N
dc.contributor.authorDrenos, F
dc.contributor.authorSim, X
dc.contributor.authorSmith, AV
dc.contributor.authorAmin, N
dc.contributor.authorBlakemore, AIF
dc.contributor.authorBork-Jensen, J
dc.contributor.authorBrandslund, I
dc.contributor.authorFarmaki, A-E
dc.contributor.authorFava, C
dc.contributor.authorFerreira, T
dc.contributor.authorHerzig, K-H
dc.contributor.authorGiri, A
dc.contributor.authorGiulianini, F
dc.contributor.authorGrove, ML
dc.contributor.authorGuo, X
dc.contributor.authorHarris, SE
dc.contributor.authorHave, CT
dc.contributor.authorHavulinna, AS
dc.contributor.authorZhang, H
dc.contributor.authorJorgensen, ME
dc.contributor.authorKarajamaki, A
dc.contributor.authorKooperberg, C
dc.contributor.authorLinneberg, A
dc.contributor.authorLittle, L
dc.contributor.authorLiu, Y
dc.contributor.authorBonnycastle, LL
dc.contributor.authorLu, Y
dc.contributor.authorMagi, R
dc.contributor.authorMahajan, A
dc.contributor.authorMalerba, G
dc.contributor.authorMarioni, RE
dc.contributor.authorMei, H
dc.contributor.authorMenni, C
dc.contributor.authorMorrison, AC
dc.contributor.authorPadmanabhan, S
dc.contributor.authorPalmas, W
dc.contributor.authorPoveda, A
dc.contributor.authorRauramaa, R
dc.contributor.authorRayner, NW
dc.contributor.authorRiaz, M
dc.contributor.authorRice, K
dc.contributor.authorRichard, MA
dc.contributor.authorSmith, JA
dc.contributor.authorSoutham, L
dc.contributor.authorStancakova, A
dc.contributor.authorStirrups, KE
dc.contributor.authorTragante, V
dc.contributor.authorTuomi, T
dc.contributor.authorTzoulald, I
dc.contributor.authorVarga, TV
dc.contributor.authorWeiss, S
dc.contributor.authorYiorkas, AM
dc.contributor.authorYoung, R
dc.contributor.authorZhang, W
dc.contributor.authorBarnes, MR
dc.contributor.authorCabrera, CP
dc.contributor.authorGao, H
dc.contributor.authorBoehnke, M
dc.contributor.authorBoerwinkle, E
dc.contributor.authorChambers, JC
dc.contributor.authorConnell, JM
dc.contributor.authorChristensen, CK
dc.contributor.authorde Boer, RA
dc.contributor.authorDeary, IJ
dc.contributor.authorDedoussis, G
dc.contributor.authorDeloukas, P
dc.contributor.authorDominiczak, AF
dc.contributor.authorDorr, M
dc.contributor.authorJoehanes, R
dc.contributor.authorEdwards, TL
dc.contributor.authorEsko, T
dc.contributor.authorFornage, M
dc.contributor.authorFranceschini, N
dc.contributor.authorFranks, PW
dc.contributor.authorGambaro, G
dc.contributor.authorGroop, L
dc.contributor.authorHallmans, G
dc.contributor.authorHansen, T
dc.contributor.authorHayward, C
dc.contributor.authorHeikki, O
dc.contributor.authorIngelsson, E
dc.contributor.authorTuomilehto, J
dc.contributor.authorJarvelin, M-R
dc.contributor.authorKardia, SLR
dc.contributor.authorKarpe, F
dc.contributor.authorKooner, JS
dc.contributor.authorLakka, TA
dc.contributor.authorLangenberg, C
dc.contributor.authorLind, L
dc.contributor.authorLoos, RJF
dc.contributor.authorLaakso, M
dc.contributor.authorMcCarthy, MI
dc.contributor.authorMelander, O
dc.contributor.authorMohlke, KL
dc.contributor.authorMoris, AP
dc.contributor.authorPalmer, CNA
dc.contributor.authorPedersen, O
dc.contributor.authorPolasek, O
dc.contributor.authorPoulter, NR
dc.contributor.authorProvince, MA
dc.contributor.authorPsaty, BM
dc.contributor.authorRidker, PM
dc.contributor.authorRotter, JI
dc.contributor.authorRudan, I
dc.contributor.authorSalomaa, V
dc.contributor.authorSamani, NJ
dc.contributor.authorSever, PJ
dc.contributor.authorSkaaby, T
dc.contributor.authorStafford, JM
dc.contributor.authorStarr, JM
dc.contributor.authorvan der Harst, P
dc.contributor.authorvan der Meer, P
dc.contributor.authorvan Duijn, CM
dc.contributor.authorVergnaud, A-C
dc.contributor.authorGudnason, V
dc.contributor.authorWareham, NJ
dc.contributor.authorWilson, JG
dc.contributor.authorWiller, CJ
dc.contributor.authorWitte, DR
dc.contributor.authorZeggini, E
dc.contributor.authorSaleheen, D
dc.contributor.authorButterworth, AS
dc.contributor.authorDanesh, J
dc.contributor.authorAsselbergs, FW
dc.contributor.authorWain, LV
dc.contributor.authorEhret, GB
dc.contributor.authorChasman, DI
dc.contributor.authorCaulfield, MJ
dc.contributor.authorElliott, P
dc.contributor.authorLindgren, CM
dc.contributor.authorLevy, D
dc.contributor.authorNewton-Cheh, C
dc.contributor.authorMunroe, PB
dc.contributor.authorHowson, JMM
dc.contributor.authorGrp, USS
dc.contributor.authorCHARGE, EBPCHDEEB
dc.contributor.authorCo, UKBC-MT
dc.contributor.authorCHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia
dc.contributor.authorThe UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group
dc.date.accessioned2019-04-05T10:25:21Z
dc.date.available2017-08-17
dc.date.available2019-04-05T10:25:21Z
dc.date.issued2017-10-13
dc.identifier.issn1942-325X
dc.identifier.otherUNSP e001778
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/56729
dc.description.abstractBackground— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. Methods and Results— Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant (P<5×10−8) for BP, of which 4 are new BP loci: rs9678851 (missense, SLC4A1AP), rs7437940 (AFAP1), rs13303 (missense, STAB1), and rs1055144 (7p15.2). In addition, we identified a potentially independent novel BP-associated SNV, rs3416322 (missense, SYNPO2L) at a known locus, uncorrelated with the previously reported SNVs. Two SNVs are associated with expression levels of nearby genes, and SNVs at 3 loci are associated with other traits. One SNV with a minor allele frequency <0.01, (rs3025380 at DBH) was genome-wide significant. Conclusions— We report 4 novel loci associated with BP regulation, and 1 independent variant at an established BP locus. This analysis highlights several candidate genes with variation that alter protein function or gene expression for potential follow-up. © 2017 American Heart Association, Inc.en_US
dc.language.isoenen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofCIRCULATION-CARDIOVASCULAR GENETICS
dc.subjectblood pressureen_US
dc.subjectexomeen_US
dc.subjectgeneticsen_US
dc.subjectgenotypeen_US
dc.subjectsample sizeen_US
dc.titleNew Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individualsen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/CIRCGENETICS.117.001778
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424292400015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume10en_US
dcterms.dateAccepted2017-08-17
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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