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Prostate cancer targeting using replication-selective adenoviruses in combination with phytochemicals
(2009)
Oncolytic adenoviral mutants have demonstrated good safety profiles but, despite some
encouraging clinical results, efficacy as a single agent was limited. Combinations with
conventional chemo- or radiotherapy significantly ...
The correlation of keratin expression with in-vitro epithelial cell line differentiation
(2009)
The mechanism of transcriptional regulation which allows oral mucosal-specific
expression of the human keratin 13 (K13) gene remains unknown. The pattern of
expression of keratin genes in the oral mucosa shows sequential ...
The relationship of human chorionic gonadotropin beta (hCGβ) expression and luteinizing hormone gene mutation (vLH) with prostate cancer in population groups of multi-ethnic origin
(2007)
Data have shown that Black men have the highest incidence and mortality from prostate cancer in the world. Even after adjusting for stage at diagnosis, black men have higher mortality rates than white men (Freedland, 2005). ...
Identification of adenovirus E1A gene regions involved in chemosensitisation of prostate cancer cells
(2009)
Replication-selective adenoviruses are promising anti-cancer therapies
(virotherapy). Viruses can be engineered to selectively target cancer cells by
deleting viral genes involved in cell cycle regulation. These deletions ...
Rapid Access Chest Pain Clinics: characteristics and outcomes of patients from six centres
(2009)
Background Despite the widespread proliferation of rapid access chest pain clinics (RACPCs), there remain outstanding questions about their effectiveness. The aim of my thesis is to determine:
Aim 1) the variation in the ...
Discovery of novel molecular and biochemical predictors of response and outcome in diffuse large B-cell lymphoma
(2009)
Discovery of Novel Molecular and Biochemical Predictors
of Response and Outcome in Diffuse Large B-cell Lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the commonest form of non-Hodgkin
lymphoma and responds to treatment ...
An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation
(2009)
Some recombinant bacterial strains have been shown to be very efficient in
experimental therapies against cancer in rodent models. Amongst them is an E. coli
that expresses the Listeriolysin-O protein (LLO) and a model ...
Global analysis of SNPs, proteins and protein-protein interactions: approaches for the prioritisation of candidate disease genes.
(2009)
Understanding the etiology of complex disease remains a challenge in biology. In recent
years there has been an explosion in biological data, this study investigates machine
learning and network analysis methods as tools ...
Determining new functions of Adenovirus VA-RNAI and its use in cancer therapy
(2009)
Virus-Associated RNA I (VA-RNAI; VAI) of adenovirus is a nontranslated
RNA molecule known to interact with several dsRNA-binding
molecules in host cells. Adenovirus lacking VA-RNAI shows reduced
replication and toxicity ...
The impact of molecular alterations and the immune microenvironment on the natural history of Follicular Lymphoma including transformation to Diffuse Large B cell Lymphoma
(2009)
The natural history of follicular lymphoma is heterogeneous with numerous relapses
and remissions over many years. A substantial number of patients suffer an
aggressive disease course with death due to disease within 5 ...