Browsing Queen Mary University of London Theses by Issue Date
Now showing items 21-40 of 4275
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Characterisation of Proendothelin-1 Derived Peptides and Evaluation of Their Utility as Biomarkers of Vascular and Renal Pathologies
(Queen Mary University of London, 02/06/2014)Endothelin-1 (ET-1), the potent vasoconstrictor peptide, is synthesised from the 212 amino acid precursor preproendothelin-1 (ppET-1). ET-1 is strongly implicated in cardiac and renal pathologies. However, ET receptor ... -
Antibiotic Resistance in Gram-negative Bacteria in Brunei Darussalam: Molecular Characterisation, Epidemiology, Surveillance and Virulence
(Queen Mary University of London, 02/09/2019)Antimicrobial resistance (AMR) presents a global threat to human and animal health. Southeast Asia (SEA) is seen as a potential hotspot for the emergence and dissemination of new resistance mechanisms. The World Health ... -
Design, Modelling, and Characterisation of Millimetre-Wave Antennas for 5G Wireless Applications
(Queen Mary University of London, 02/10/2018)Future 5G systems and beyond are expected to implement compact and versatile antennas in highly densifi ed millimetre-wave (MMW) wireless networks. This research emphasises on the realisation of 5G antennas provided with ... -
The indirect impacts of ecosystem engineering by invasive crayfish
(Queen Mary University of London, 02/10/2018)Bioturbation by invasive crayfish can significantly alter sediment properties and its transport in invaded water bodies; however, the indirect impacts of this on ecosystem functioning are poorly understood. In this thesis ... -
Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia
(Queen Mary University of London, 02/10/2018)High plasma levels of inflammatory mediator, high mobility group box protein 1 (HMGB1), and its main receptor, receptor for advanced glycation end products (RAGE), is associated with poor prognosis for a variety of cancers, ... -
Citrobacter rodentium infection in mice to dissect host pathogen relationship in the gut
(Queen Mary University of London, 02/11/2016)Citrobacter rodentium is a gut pathogen, which infects the distal colon of mice. It has many similarities to human Enteropathogenic and Enterohemorrhagic E.coli in terms of mechanisms of pathogenicity and methods of ... -
Inside teenage bedrooms A cross-generational study of the teenage bedroom and its material culture
(Queen Mary University of London, 02/12/2016)It has been suggested (Zeiher & Zeiher, 1991; Gillis, 2008) that contemporary Western childhood has become increasingly ‘islanded’ – lived out in the specialized spaces dedicated to children that are conceived both for the ... -
HUMAN RIGHTS APPROACH IN GLOBAL INTELLECTUAL PROPERTY REGIME: WITH CASE STUDIES ON THE US-KOREA FTA AND THE EUKOREA FTA
(Queen Mary University of London, 03/03/2018)From its emergence to its expansion, intellectual property (IP) has not been isolated from trade. However, in the late 1970s, business interests in the United States (US) exerted powerful pressure, leading to IP norms ... -
Three-Dimensional Reconstruction of Braided River Morphology and Morphodynamics with Structure-from-Motion Photogrammetry
(Queen Mary University of London, 03/03/2018)The recent emergence of Structure-from-Motion Photogrammetry (SfM) has created a cost-effective alternative to conventional laser scanning for the production of high-resolution topographic datasets. There has been an ... -
COMPULSORY LICENSING FOR PHARMACEUTICAL PATENTS: EXAMINING THE CONSISTENCY OF THE LOCAL WORKING REQUIREMENTS UNDER SECTION 84 OF THE INDIAN PATENT ACT WITH THE TRIPS AGREEMENT AS A MODEL FOR GHANA
(Queen Mary University of London, 03/05/2019)Compulsory licensing would offer Ghana a practical means to mitigate the high costs and shortages of medicines resulting from the failure of patentees to work their patented medicines locally. Article 5(A) of the Paris ... -
National Cultures and Employee Commitment in Nigerian Organisations: Exploring Conflicts and Relationships
(Queen Mary University of London, 03/06/2019)This PhD thesis explores how core national cultural values of ethnically diverse employees in Nigeria influence their understanding/views of organisational values and their commitment to these values. The study is motivated ... -
Hydrodynamic performance of HAMCTs in steady and unsteady flows
(Queen Mary University of London, 03/07/2019)The hydrodynamic performance of the common three-blades horizontal axis current turbine (HAMCT) is computationally investigated to seek paths of improvement. Two computational approaches are used, namely the Blade Element ... -
Real-Time Sound Synthesis of Aeroacoustic Sounds using Physically Derived Models
(Queen Mary University of London, 03/07/2019)This thesis examines the use of a novel synthesis approach to reproduce aeroacoustic sound effects. This requires research into the fi eld of fluid dynamics to understand the principles which lead to a number of fundamental ... -
A framework for the design and evaluation of magic tricks that utilises computational systems configured with psychological constraints
(Queen Mary University of London, 03/12/2014)A human magician blends science, psychology and performance to create a magical e ect. This thesis explores what can be achieved when that human intelligence is replaced or assisted by machine intelligence. Magical e ects ... -
A Study of Effects on MMP14 Transcriptional Regulation and Angiogenesis by Hypoxia and Statins
(Queen Mary University of London, 03/12/2014)Atheromas contain hypoxic areas which upregulate HIF1α expression, promoting angiogenesis and unstable lesion formation. Simvastatin stabilises atheromas through preventing rupture and neovascularisation. Atheromas express ... -
Interaction between Vascular Endothelial Cells and Surface Textured Biomaterials
(Queen Mary University of London, 03/12/2014)A promising approach to overcome thrombus and neointima formation on vascular grafts is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. Surface topography of these implants is ... -
Manipulation and Imaging of Interactions Between Layer-by-layer Capsules and Live Cells Using Nanopipettes and SICM
(Queen Mary University of London, 03/12/2018)Usability of many chemical substances with significant potential for biomedical applications is limited by their poor solubility in water or limited stability in the physiological environment. One of promising strategies ... -
Hydrodynamics of Gravel Bed Flows (Implication on Colmation)
(Queen Mary University of London, 04/02/2015)Bottom of the mountainous rivers is generally composed of natural gravels. Flow depth in such rivers is generally shallow, with the ratio of water depth to size of bed materials (known as relative submergence) rarely higher ... -
Oesophageal hypersensitivity in patients with gastro-oesophageal reflux symptoms: Prevalence and novel treatments
(Queen Mary University of London, 04/02/2019)Background Gastro oesophageal reflux disease (GORD) is a leading cause of morbidity and economic importance worldwide. It is currently defined by the Montreal definition as a condition, which develops when the reflux of ... -
Metasin: An Intra-Operative Real-Time Quantitative Reverse Transcription Polymerase-Chain Reaction (RTqPCR) Assay to Detect Metastatic Breast Cancer in Sentinel Lymph Nodes
(Queen Mary University of London, 04/04/2014)The most important prognostic factor in breast cancer is the presence or absence of metastases in axillary lymph nodes. Frozen section and touch imprint cytology are conventional intra-operative methods used in the detection ...
