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Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection
(Public Library of Science, 2012-09-27)
Background
Urogenital schistosomiasis is caused by the helminth parasite Schistosoma haematobium. In high transmission areas, children acquire schistosome infection early in life with infection levels peaking in early ...
The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production
(Elsevier/Science Direct, 2011-10-14)
In this study, infective larvae of the parasitic helminth Schistosoma mansoni were shown to contain a large number of glycosylated components specific for the Mannose Receptor (MR; CD206), which is an important pattern ...
CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1
(Public Library of Science, 2014-08-07)
Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total ...
Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive
(Public Library of Science, 2015-05-14)
The skin provides an important first line of defence and immunological barrier to invasive pathogens, but immune responses must also be regulated to maintain barrier function and ensure tolerance of skin surface commensal ...
Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels
(Public Library of Science, 2011-05-06)
In animal experimental models, parasitic helminth infections can protect the host from auto-immune diseases. We conducted a population-scale human study investigating the relationship between helminth parasitism and ...
Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium
(Nature Publishing Group, 2012-06-26)
Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human ...
Chitinase 3-Like 1 Protein Levels Are Elevated in Schistosoma haematobium Infected Children
(Public Library of Science, 2012-11-08)
Currently there are few studies characterising the nature and aetiology of human schistosome-related inflammatory processes. The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also ...
Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection
(Elsevier/Science Direct, 2015-01-06)
Keratinocytes constitute the majority of cells in the skin’s epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, ...
Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses
(Wolters Kluwer Health Inc., 2019-07)
BACKGROUND:
Children with critical illness have increased intestinal permeability and a period of immunoparalysis, mediated by elevated circulating endotoxin. Whether children with less severe infections have similar ...