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Socioeconomic status and disease-modifying therapy prescribing patterns in people with multiple sclerosis.
(2020-02-24)
AIMS: To examine the association between socioeconomic status (SES) and disease-modifying therapy (DMT) prescribing patterns in people with relapsing-remitting multiple sclerosis (pwRRMS). METHODS: A cross-sectional analysis ...
Multiple organ dysfunction after trauma
(2020-03)
Early Identification of Trauma-induced Coagulopathy: Development and Validation of a Multivariable Risk Prediction Model.
(2020-01-14)
OBJECTIVE: The aim of this study was to develop and validate a risk prediction tool for trauma-induced coagulopathy (TIC), to support early therapeutic decision-making. BACKGROUND: TIC exacerbates hemorrhage and is associated ...
Refining rodent models of spinal cord injury.
(Elsevier, 2020-03-03)
This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury ...
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors.
(2020-01-22)
N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the ...
Prior Antiplatelet Therapy, Excluding Phosphodiesterase Inhibitor Is Associated with Poor Outcome in Patients with Spontaneous Intracerebral Haemorrhage.
(2020-04)
There is conflicting results on whether prior antiplatelet therapy (APT) is associated with poor outcome in spontaneous intracerebral haemorrhage (ICH) patients. To determine whether prior APT is associated with spontaneous ...