• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Trans-ethnic association study of blood pressure determinants in over 750,000 individuals 
    •   QMRO Home
    • William Harvey Research Institute
    • Clinical Pharmacology
    • Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
    •   QMRO Home
    • William Harvey Research Institute
    • Clinical Pharmacology
    • Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

    View/Open
    Accepted version
    Embargoed until: 2019-04-29
    Reason: post-print restrictions: 6 months embargo
    Volume
    51
    Pagination
    51 - +
    Publisher
    Nature Publishing Group
    DOI
    10.1038/s41588-018-0303-9
    Journal
    NATURE GENETICS
    Issue
    1
    ISSN
    1061-4036
    Metadata
    Show full item record
    Abstract
    In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
    Authors
    Giri, A; Hellwege, JN; Keaton, JM; Park, J; Qiu, C; Warren, HR; Torstenson, ES; Kovesdy, CP; Sun, YV; Wilson, OD
    URI
    https://qmro.qmul.ac.uk/xmlui/handle/123456789/55066
    Collections
    • Clinical Pharmacology [115]
    Licence information
    To obtain permission to re-use content from this article visit RightsLink.
    Copyright statements
    The Author(s), under exclusive licence to Springer Nature America, Inc. 2018
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.