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dc.contributor.authorShakoor, S
dc.contributor.authorZavos, HMS
dc.contributor.authorMcGuire, P
dc.contributor.authorCardno, AG
dc.contributor.authorFreeman, D
dc.contributor.authorRonald, A
dc.date.accessioned2019-01-30T11:50:33Z
dc.date.available2019-01-30T11:50:33Z
dc.date.issued2015-06-30
dc.identifier.citationShakoor, S., et al. (2015). "Psychotic experiences are linked to cannabis use in adolescents in the community because of common underlying environmental risk factors." Psychiatry Research 227(2): 144-151en_US
dc.identifier.issn0165-1781
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/55009
dc.description.abstractCannabis users are more likely to have psychotic experiences (PEs). The degree to which these associations are driven by genetic or environmental influences in adolescence is unknown. This study estimated the genetic and environmental contributions to the relationship between cannabis use and PEs. Specific PEs were measured in a community-based twin sample (4830 16-year-old pairs) using self-reports and parent-reports. Adolescents reported on ever using cannabis. Multivariate liability threshold structural equation model-fitting was conducted. Cannabis use was significantly correlated with PEs. Modest heritability (37%), common environmental influences (55%) and unique environment (8%) were found for cannabis use. For PEs, modest heritability (27–54%), unique environmental influences (E=12–50%) and little common environmental influences (11–20%), with the exception of parent-rated Negative Symptoms (42%), were reported. Environmental influences explained all of the covariation between cannabis use and paranoia, cognitive disorganization and parent-rated negative symptoms (bivariate common environment=69–100%, bivariate unique environment=28–31%), whilst the relationship between cannabis use and hallucinations indicated familial influences. Cannabis use explains 2–5% of variance in positive, cognitive, and negative PEs. Cannabis use and psychotic experience co-occur due to environmental factors. Focus on specific environments may reveal why adolescent cannabis use and psychotic experiences tend to ‘travel together’.en_US
dc.description.sponsorshipMedical Research Council [G1100559 to Angelica Ronald]. TEDS is funded by the Medical Research Council [G0901245 and, previously, G0500079 to Robert Plomin]. Daniel Freeman was supported by the Medical Research Council [G0902308].en_US
dc.format.extent144 - 151
dc.language.isoenen_US
dc.publisherElsevier/Science Directen_US
dc.relation.ispartofPsychiatry Research
dc.rightsCreative Commons Attribution License
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectPsychotic experiencesen_US
dc.subjectCannabis useen_US
dc.subjectGeneticsen_US
dc.subjectTwin Studyen_US
dc.subjectAdolescenceen_US
dc.titlePsychotic experiences are linked to cannabis use in adolescents in the community because of common underlying environmental risk factorsen_US
dc.typeArticleen_US
dc.rights.holder2015 The Authors
dc.identifier.doi10.1016/j.psychres.2015.03.041
pubs.issue2-3en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume227en_US
dcterms.dateAccepted2015-03-27
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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