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dc.contributor.authorAlthunayyan, Aen_US
dc.contributor.authorPetersen, SEen_US
dc.contributor.authorLloyd, Gen_US
dc.contributor.authorBhattacharyya, Sen_US
dc.date.accessioned2018-12-03T14:33:32Z
dc.date.available2018-11-20en_US
dc.date.issued2018-11-28en_US
dc.date.submitted2018-11-20T17:30:26.435Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/53470
dc.description.abstractINTRODUCTION: Mitral valve prolapse is a common valve pathology with a spectrum of disease from isolated prolapse to myxomatous, multi-scallop Barlow's disease. The main complications relate to progression of mitral regurgitation, endocarditis, sudden death and stroke. The timing of intervention in patients with asymptomatic severe mitral regurgitation is controversial. Areas covered: This article reviews the pathophysiology, genetics, clinical features, diagnostic imaging, complications, long term outcomes and indications for intervention in mitral valve prolapse. Expert commentary: Several key dilemmas in the management of mitral valve prolapse remain. Factors which influence progression of mitral regurgitation are unclear and therefore we have no therapeutic targets to prevent progression. Evidence-based methods to reduce the risk of sudden death, stroke and endocarditis have not been identified. In symptomatic patients with severe mitral regurgitation valve surgery is recommended. In asymptomatic patients, careful risk stratification incorporating markers of left ventricular dysfunction, atrial fibrillation, pulmonary hypertension and valve reparability is required to identify the optimal timing of intervention.en_US
dc.description.sponsorshipThis paper was not funded.en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofExpert Rev Cardiovasc Theren_US
dc.rights“This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Cardiovascular Therapy on 28 Nov 2018, available online: https://doi.org/10.1080/14779072.2019.1553619.”
dc.subjectEchocardiographyen_US
dc.subjectHeart valvesen_US
dc.subjectcardiac surgeryen_US
dc.subjectdegenerative mitral regurgitationen_US
dc.subjectmitral regurgitationen_US
dc.subjectmitral valve prolapseen_US
dc.titleMitral valve prolapse.en_US
dc.typeArticle
dc.identifier.doi10.1080/14779072.2019.1553619en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30484338en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
qmul.funderNIHR BRC at Barts::National Institute of Health Researchen_US


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