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    Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling 
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    • Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling
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    • Institute of Dentistry
    • Centre for Oral Immunobiology and Regenerative Medicine
    • Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling
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    Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling

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    WANTwoMechanisms2012FINAL.pdf (814.1Kb)
    Volume
    7
    Pagination
    e38599 - ?
    DOI
    10.1371/journal.pone.0038599
    Issue
    6
    Metadata
    Show full item record
    Abstract
    Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles. However, in certain clinical situations including oral lichen planus, K15 is induced in suprabasal layers, which is inconsistent with the role of a stem cell marker. This study provides insights into the mechanisms of K15 expression in the basal and differentiating keratinocytes.
    Authors
    Bose, A; Teh, MT; Hutchison, IL; Wan, H; Leigh, IM; Waseem, A
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/5301
    Collections
    • Centre for Oral Immunobiology and Regenerative Medicine [394]
    Language
    eng
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