• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    SUMOylation is required for optimal TRAF3 signaling capacity. 
    •   QMRO Home
    • Barts Cancer Institute
    • Centre for Molecular Oncology
    • SUMOylation is required for optimal TRAF3 signaling capacity.
    •   QMRO Home
    • Barts Cancer Institute
    • Centre for Molecular Oncology
    • SUMOylation is required for optimal TRAF3 signaling capacity.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    SUMOylation is required for optimal TRAF3 signaling capacity.

    View/Open
    Accepted version (2.195Mb)
    Volume
    8
    Pagination
    e80470 - ?
    DOI
    10.1371/journal.pone.0080470
    Journal
    PLoS One
    Issue
    11
    Metadata
    Show full item record
    Abstract
    TNF receptor-associated factors (TRAFs) are multifunctional adaptor proteins involved in temporal and spatial coordination of signals necessary for normal immune function. Here, we report that TRAF3, a TRAF family member with a key role in Toll-like and TNF family receptor signaling and suppressor of lymphomagenesis, is post-translationally modified by the small ubiquitin-related modifier (SUMO). Through yeast two-hybrid and co-immunoprecipitation assays we have identified Ubc9, the SUMO conjugating enzyme, as a novel TRAF3-interacting protein. We show that Ubc9-dependent SUMOylation of TRAF3 modulates optimal association with the CD40 receptor, thereby influencing TRAF3 degradation and non-canonical NF-κB activation upon CD40 triggering. Collectively, our findings describe a novel post-translational modification of a TRAF family member and reveal a link between SUMOylation and TRAF-mediated signal transduction.
    Authors
    Miliara, S; Gkouskou, KK; Sharp, TV; Eliopoulos, AG
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/44303
    Collections
    • Centre for Molecular Oncology [260]
    Language
    eng
    Licence information
    Creative Commons Attribution License
    Copyright statements
    2013 Miliara et al
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.