• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Microsomal membranes from antigen presenting cells present antigenic peptides to T cells: a novel approach in vaccine development. 
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Microsomal membranes from antigen presenting cells present antigenic peptides to T cells: a novel approach in vaccine development.
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Microsomal membranes from antigen presenting cells present antigenic peptides to T cells: a novel approach in vaccine development.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Microsomal membranes from antigen presenting cells present antigenic peptides to T cells: a novel approach in vaccine development.

    View/Open
    SOFRAMicrosomalMembranes2010.pdf (3.966Mb)
    Publisher
    Queen Mary University of London
    Metadata
    Show full item record
    Abstract
    The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective vaccines are potent in generating neutralizing antibody responses. Nonetheless, vaccination fails to protect against a wide range of acquired chronic infections caused by viruses, such as HIV and HCV, other intracellular pathogens, and cancer. Attempts to combat these diseases are thought to require the induction of the cellular arm of the immune response, in which dendritic cells (DCs) play a key role. Thus, DCs are now considered a promising target/tool when designing new-generation vaccines. Although mature DCs have the capacity to induce effective primary and secondary immune responses in vivo, their use in vaccination strategies is associated with several difficulties; for example, there are limitations involved in the loading of antigen, and in the appropriate maturation of DC in vitro. In this study, we have explored the hypothesis that the use of ERenriched microsomes isolated from professional antigen presenting cells, such as DCs, can represent an alternative vaccination strategy to those using live DCs. Endoplasmic reticulum-enriched microsomal membranes (microsomes) isolated from DCs contained high levels of peptide-receptive major histocompatibility complex (MHC) and co-stimulatory molecules. After loading with defined antigenic peptides, injected microsomes mediated MHC class I- and MHC class II-restricted T cell responses. The microsomal vaccine described and discussed in this thesis protects from a viral infection and was shown to regress an established murine tumor. Therefore, it could represent an exciting new alternative to currently available vaccine strategies.
    Authors
    Sofra, Vasiliki
    URI
    https://qmro.qmul.ac.uk/xmlui/handle/123456789/428
    Collections
    • Theses [3348]
    Copyright statements
    The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.