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dc.contributor.authorCoelewij, Len_US
dc.contributor.authorCurtis, Den_US
dc.date.accessioned2018-07-31T08:48:34Z
dc.date.available2018-06-05en_US
dc.date.issued2018-09en_US
dc.date.submitted2018-06-20T15:03:37.964Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/42744
dc.description.abstractA number of important findings have recently emerged relevant to identifying genetic risk factors for schizophrenia. Findings using common variants point towards gene sets of interest and also demonstrate an overlap with other psychiatric and nonpsychiatric disorders. Imputation of variants of the gene for complement component 4 (C4) from GWAS data has shown that the predicted expression of the C4A product is associated with schizophrenia risk. Very rare variants disrupting SETD1A, RBM12 or NRXN1 have a large effect on risk. Other rare, damaging variants are enriched in genes that are loss of function intolerant and/or whose products localise to the synapse. These and particular copy number variants can result in increased risk of schizophrenia but also of other neurodevelopmental disorders. The findings for C4 and NRXN1 may be especially helpful for elucidating the biological mechanisms that can lead to disease.en_US
dc.format.extent239 - 243en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofAnn Hum Geneten_US
dc.rights"This is the peer reviewed version of the following article: Coelewij L, Curtis D. Mini‐review: Update on the genetics of schizophrenia. Ann Hum Genet. 2018;1–5. https://doi.org/10.1111/ahg.12259 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
dc.subjectC4en_US
dc.subjectCNVen_US
dc.subjectNRXNen_US
dc.subjectRBM12en_US
dc.subjectSETD1Aen_US
dc.subjectgeneticsen_US
dc.subjectschizophreniaen_US
dc.titleMini-review: Update on the genetics of schizophrenia.en_US
dc.typeArticle
dc.identifier.doi10.1111/ahg.12259en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29923609en_US
pubs.issue5en_US
pubs.notesNo embargoen_US
pubs.publication-statusPublisheden_US
pubs.volume82en_US
dcterms.dateAccepted2018-05-18en_US


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