Browsing Centre for Medical Education by Author "August, E"

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Feedback control architecture and the bacterial chemotaxis network.

Hamadeh, A; Roberts, MAJ; August, E; McSharry, PE; Maini, PK; Armitage, JP; Papachristodoulou, A (2011-05)

Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to ...
A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway in R. sphaeroides.

Roberts, MAJ; August, E; Hamadeh, A; Maini, PK; McSharry, PE; Armitage, JP; Papachristodoulou, A (2009-10-31)

BACKGROUND: Developing methods for understanding the connectivity of signalling pathways is a major challenge in biological research. For this purpose, mathematical models are routinely developed based on experimental ...