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dc.contributor.authorCutts, RJ
dc.contributor.authorGuerra-Assunção, JA
dc.contributor.authorGadaleta, E
dc.contributor.authorDayem Ullah, AZ
dc.contributor.authorChelala, C
dc.descriptionThis article has been accepted for publication in Nucleic Acids Research 2015 Jan;43(Database issue):D831-6. doi: 10.1093/nar/gku984. Epub 2014 Oct 20. Published by Oxford University Press.en_US
dc.description.abstractBCCTBbp (http://bioinformatics.breastcancertissue was initially developed as the data-mining portal of the Breast Cancer Campaign Tissue Bank (BCCTB), a vital resource of breast cancer tissue for researchers to support and promote cutting-edge research. BCCTBbp is dedicated to maximising research on patient tissues by initially storing genomics, methylomics, transcriptomics, proteomics and microRNA data that has been mined from the literature and linking to pathways and mechanisms involved in breast cancer. Currently, the portal holds 146 datasets comprising over 227,795 expression/genomic measurements from various breast tissues (e.g. normal, malignant or benign lesions), cell lines and body fluids. BCCTBbp can be used to build on breast cancer knowledge and maximise the value of existing research. By recording a large number of annotations on samples and studies, and linking to other databases, such as NCBI, Ensembl and Reactome, a wide variety of different investigations can be carried out. Additionally, BCCTBbp has a dedicated analytical layer allowing researchers to further analyse stored datasets. A future important role for BCCTBbp is to make available all data generated on BCCTB tissues thus building a valuable resource of information on the tissues in BCCTB that will save repetition of experiments and expand scientific knowledge.en_US
dc.description.sponsorshipBreast Cancer Campaign Tissue Bank [09TBBAR]; Cancer Research UK [15310 to A.Z.D.U.]. Funding for open access charge: Breast Cancer Campaign [09TBBAR]en_US
dc.format.extentD831 - D836
dc.publisherOxford University Pressen_US
dc.relation.ispartofNucleic Acids Res
dc.rightsCreative Commons Attribution License
dc.subjectBreast Neoplasmsen_US
dc.subjectComputational Biologyen_US
dc.subjectDatabases, Geneticen_US
dc.subjectGene Expression Profilingen_US
dc.subjectTissue Banksen_US
dc.titleBCCTBbp: the Breast Cancer Campaign Tissue Bank bioinformatics portal.en_US
dc.rights.holder2014. The authors
pubs.issueDatabase issue
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Barts Cancer Institute
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Barts Cancer Institute/Molecular Oncology

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