Browsing Centre for Endocrinology by Subject "Neuroendocrine Tumors"

Now showing items 1-3 of 3

    • From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal. 

      Asa, SL; Casar-Borota, O; Chanson, P; Delgrange, E; Earls, P; Ezzat, S; Grossman, A; Ikeda, H; Inoshita, N; Karavitaki, N (2017-04)
      The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive ...

    • MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. 

      Iacovazzo, D; Flanagan, SE; Walker, E; Quezado, R; de Sousa Barros, FA; Caswell, R; Johnson, MB; Wakeling, M; Brändle, M; Guo, M (2018-01-30)
      The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants ...

    • Novel AIP mutation in exon 6 causing acromegaly in a German family. 

      Detomas, M; Altieri, B; Flitsch, J; Saeger, W; Korbonits, M; Deutschbein, T (2023-08)
      The most frequent genetic alteration of familial isolated growth hormone producing pituitary neuroendocrine tumors is a germline mutation of the aryl hydrocarbon receptor-interacting protein (AIP) gene. Various AIP mutations ...