Browsing Centre for Endocrinology by Subject "Mice, Knockout"
Now showing items 1-2 of 2
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Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty.
(2018-02-01)Context: Self-limited delayed puberty (DP) is often associated with a delay in physical maturation, but although highly heritable the causal genetic factors remain elusive. Genome-wide association studies of the timing of ... -
T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.
(2015-04-16)Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion ...