Now showing items 1-10 of 23
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
(Nature Research (part of Springer Nature), 2019-02-18)
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ...
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
(Oxford University Press, 2019-01-29)
An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ...
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)
Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ...