Now showing items 11-20 of 35
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
(Springer Nature, 2019-01-07)
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking ...
The narrow-sense and common single nucleotide polymorphism heritability of early repolarization.
BACKGROUND: Early repolarization (ER) is a risk marker for sudden cardiac death. Higher risk is associated with horizontal/descending ST-segment ER in the inferior or inferolateral ECG leads. Studies in family cohorts have ...
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
(Nature Research (part of Springer Nature), 2019-02-18)
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ...
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
(Nature Publishing Group, 2019-01-24)
Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR ...
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)
Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ...
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
(Nature Research (part of Springer Nature), 2018-11-14)
Correction to: Nature Genetics https://doi.org/10.1038/s41588-018-0205-x, published online 17 September 2018. In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly ...