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Now showing items 91-100 of 116
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
(Nature Research (part of Springer Nature), 2014-12-12)
DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide methylated DNA immunoprecipitation sequencing (MeDIP-seq) in ...
Classical Flt3L-dependent dendritic cells control immunity to protein vaccine
(Rockefeller University Press, 2014-08-25)
<jats:p>DCs are critical for initiating immunity. The current paradigm in vaccine biology is that DCs migrating from peripheral tissue and classical lymphoid-resident DCs (cDCs) cooperate in the draining LNs to initiate ...
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
(Springer Science and Business Media LLC, 2014-04)
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells
(Rockefeller University Press, 2014-06-02)
PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice.
(Royal Society, 2014-05-07)
The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose ...
Anaemia secondary to critical illness: an unexplained phenomenon.
(2014-02-07)
Almost all patients suffering critical illness become anaemic during their time in intensive care. The cause of this anaemia and its management has been a topic of debate in critical care medicine for the last two decades. ...