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Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer.
(2018-08)
Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft ...
Inflammasomes: a novel therapeutic target in pulmonary hypertension?
(2018-05-30)
Pulmonary hypertension (PH) is a rare, progressive pulmonary vasculopathy characterized by increased mean pulmonary arterial pressure, pulmonary vascular remodelling and right ventricular failure. Current treatments are ...
Potassium channels in the sinoatrial node and their role in heart rate control.
(2018)
Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties ...
Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade Bodies.
(Wiley, 2018-06-28)
BACKGROUND:
Endothelial cells harbour specialised storage organelles, Weibel-Palade Bodies (WPBs). Exocytosis of WPB content into the vascular lumen initiates primary haemostasis, mediated by Von Willebrands factor (VWF) ...
EU-funded initiatives for real world evidence: descriptive analysis of their characteristics and relevance for regulatory decision-making.
(2018-06-14)
INTRODUCTION: A review of European Union (EU)-funded initiatives linked to 'Real World Evidence' (RWE) was performed to determine whether their outputs could be used for the generation of real-world data able to support ...
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.
(2018-09)
Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization in patients with spontaneous and ...
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
(2018-10)
BACKGROUND: Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular outcomes in patients with type 2 diabetes mellitus. However, systemic actions of these agents cause sympathetic activation, which is ...
Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria.
(2018-10)
Oral reduction of nitrate to nitrite is dependent on the oral microbiome and is the first step of an alternative mammalian pathway to produce nitric oxide in humans. Preliminary evidence suggests important sex differences ...