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Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters.

Miller, DC; Harmer, SC; Poliandri, A; Nobles, M; Edwards, EC; Ware, JS; Sharp, TV; McKay, TR; Dunkel, L; Lambiase, PD;... (2017-12)

The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode ...