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Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study.

Wijeysundera, DN; Beattie, WS; Hillis, GS; Abbott, TEF; Shulman, MA; Ackland, GL; Mazer, CD; Myles, PS; Pearse, RM; Cuthbertson, BH;... (2020-03)

BACKGROUND: The Duke Activity Status Index (DASI) questionnaire might help incorporate self-reported functional capacity into preoperative risk assessment. Nonetheless, prognostically important thresholds in DASI scores ...

Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.

Kallali, W; Gray, E; Mehdi, MZ; Lindsay, R; Metherell, LA; Buonocore, F; Suntharalingham, JP; Achermann, JC; Donaldson, M (2020-03)

Objective: CYP11A1 mutations cause P450 side-chain cleavage (scc) deficiency, a rare form of congenital adrenal hyperplasia with a wide clinical spectrum. We detail the phenotype and evolution in a male sibship identified ...

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Angus, DC; Derde, L; Al-Beidh, F; Annane, D; Arabi, Y; Beane, A; van Bentum-Puijk, W; Berry, L; Bhimani, Z; Bonten, M;... (2020-10-06)

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, ...

Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study.

COVIDSurg Collaborative (Wiley Periodicals LLC on behalf of American Cancer Society, 2021-07-15)

BACKGROUND: The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This international, ...

COVID-19: Causes of anxiety and wellbeing support needs of healthcare professionals in the UK: A cross-sectional survey.

Siddiqui, I; Aurelio, M; Gupta, A; Blythe, J; Khanji, MY (Royal College of Physicians, 2021-01)

BACKGROUND: COVID-19 has caused acute changes in healthcare delivery; this may impact mental health and wellbeing needs of healthcare professionals (HCPs). AIMS: We aimed to identify the causes of anxiety in HCPs during ...

Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients.

Palmas, F; Clarke, J; Colas, RA; Gomez, EA; Keogh, A; Boylan, M; McEvoy, N; McElvaney, OJ; McElvaney, O; Alalqam, R;... (Public Library of Science, 2021-08-26)

Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths worldwide. A timely coordinated host-immune response ...

2020 ESC Guidelines for the management of adult congenital heart disease.

Baumgartner, H; De Backer, J; Babu-Narayan, SV; Budts, W; Chessa, M; Diller, G-P; Lung, B; Kluin, J; Lang, IM; Meijboom, F;... (Oxford University Press, 2021-02-11)

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.

Arabi, YM; Gordon, AC; Derde, LPG; Nichol, AD; Murthy, S; Beidh, FA; Annane, D; Swaidan, LA; Beane, A; Beasley, R;... (2021-07-12)

PURPOSE: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). METHODS: Critically ill adults with COVID-19 were randomized to receive ...

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL;... (Nature Research, 2021-01-05)

Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ...

Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank.

Raisi-Estabragh, Z; McCracken, C; Bethell, MS; Cooper, J; Cooper, C; Caulfield, MJ; Munroe, PB; Harvey, NC; Petersen, SE (2020-08-18)

BACKGROUND: We examined whether the greater severity of coronavirus disease 2019 (COVID-19) amongst men and Black, Asian and Minority Ethnic (BAME) individuals is explained by cardiometabolic, socio-economic or behavioural ...