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Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.

Mills, TC; Chapman, S; Hutton, P; Gordon, AC; Bion, J; Chiche, J-D; Holloway, PAH; Stüber, F; Garrard, CS; Hinds, CJ;... (2015-09-01)

BACKGROUND: Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis ...

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Angus, DC; Derde, L; Al-Beidh, F; Annane, D; Arabi, Y; Beane, A; van Bentum-Puijk, W; Berry, L; Bhimani, Z; Bonten, M;... (2020-10-06)

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, ...

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.

Arabi, YM; Gordon, AC; Derde, LPG; Nichol, AD; Murthy, S; Beidh, FA; Annane, D; Swaidan, LA; Beane, A; Beasley, R;... (2021-07-12)

PURPOSE: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). METHODS: Critically ill adults with COVID-19 were randomized to receive ...

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.

Writing Committee for the REMAP-CAP Investigators; Higgins, AM; Berry, LR; Lorenzi, E; Murthy, S; McQuilten, Z; Mouncey, PR; Al-Beidh, F; Annane, D; Arabi, YM;... (2023-01-03)

IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: To determine the effect of multiple interventions for critically ill adults with COVID-19 ...