Now showing items 1-10 of 78
A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.
Biologic therapies have shown high efficacy in psoriasis, but individual response varies and is poorly understood. To inform biomarker discovery in the Psoriasis Stratification to Optimise Relevant Therapy (i.e., PSORT) ...
Sodium Nitrite-Mediated Cardioprotection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Cost-Effectiveness Analysis.
OBJECTIVES:: In the follow-up of patients in a trial of intracoronary sodium nitrite given during primary percutaneous coronary intervention (PCI) after acute myocardial infarction (AMI), we found a reduction in the incidence ...
Depth of Anesthesia and Postoperative Delirium
(American Medical Association (AMA), 2019-02-05)
Despite advances in medical therapies, the demand for surgery is consistently increasing.1 Each year, more than 300 million surgical procedures are performed worldwide, involving an increasingly elderly patient population.2,3 ...
Cardiovascular magnetic resonance imaging for amyloidosis: The state-of-the-art.
Amyloidosis results from insoluble precursor proteins being deposited in the extracellular compartment. The prognosis of the disease is predominantly determined by cardiac involvement due to amyloid accumulation that ...
Perioperative medicine and UK plc.
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury.
Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies such as myocardial infarction, stroke and acute kidney injury. I/R injury is characterized by a rapid influx of activated ...
Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study.
BACKGROUND: The aetiology of perioperative myocardial injury is poorly understood and not clearly linked to pre-existing cardiovascular disease. We hypothesised that loss of cardioprotective vagal tone [defined by impaired ...
Cardiac Vagus and Exercise.
(American Physiological Society, 2019-01-01)
Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in ...