Search
Now showing items 1-8 of 8
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)
Background—
Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ...
Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval.
(Elsevier, 2020-04-29)
Sudden cardiac death is responsible for half of all deaths from cardiovascular disease. The analysis of the electrophysiological substrate for arrhythmias is crucial for optimal risk stratification. A prolonged T-peak-to-Tend ...
An Academic Clinician's Road Map to Hypertension Genomics: Recent Advances and Future Directions MMXX.
(2021-01-04)
At the dawn of the new decade, it is judicious to reflect on the boom of knowledge about polygenic risk for essential hypertension supplied by the wealth of genome-wide association studies. Hypertension continues to account ...
Promise and Peril of a Genotype-First Approach to Mendelian Cardiovascular Disease.
(American Heart Association, 2024-10-18)
Precision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard-of-care for Mendelian cardiovascular disease (CVD). However, early identification and ...