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Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
(Bioscientifica, 2019-02-01)
While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or ...
Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion.
(2019-04)
Background: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionarily conserved and expressed widely throughout the organism. Loss-of-function AIP mutations predispose to young-onset pituitary adenomas. AIP ...
Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.
(Oxford University Press, 2020-03-20)
Substantial advances have been made recently in the pathobiology of pituitary tumors. Similar to many other endocrine tumors, over the last few years we have recognized the role of germline and somatic mutations in a number ...
Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations.
(2020-10-26)
CONTEXT: Aggressive pituitary tumours (APTs) are characterised by unusually rapid growth and lack of response to standard treatment. About 1-2% develop metastases being classified as pituitary carcinomas (PCs). For unknown ...
Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?
(2021-03-01)
The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The ...
