Now showing items 1-10 of 39
LB01.07: ELEVATED BLOOD PRESSURE WITHOUT HYPERTROPHY RAISES LEFT VENTRICULAR EJECTION FRACTION.
OBJECTIVE: Hypertension remains a major cause of cardiovascular morbidity and mortality worldwide. Persistent blood pressure (BP) elevation may lead to left ventricular (LV) hypertrophy and heart failure. We wanted to ...
[OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II.
OBJECTIVE: A recent genome-wide association study identified a locus within natriuretic peptide receptor C (NPR3) to be significantly associated with blood pressure (BP), To functionally characterise the effect of BP- ...
Status and future of genomics in blood pressure
Hypertension genomics and cardiovascular prevention.
Hypertension continues to be a major risk factor for global mortality, and recent genome-wide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. ...
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying ...
The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.
Elevated blood pressure (BP) is a major global risk factor for cardiovascular disease. Genome-wide association studies have identified several genetic variants at the NPR3 locus associated with BP, but the functional impact ...